https://pubmed.ncbi.nlm.nih.gov/37587287/ HEPATOLOGY

Hepatol Int. 2023 Aug 16.
doi: 10.1007/s12072-023-10571-4. Online ahead of print.

Live donor liver transplantation for pediatric acute liver failure: challenges and outcomes

Viniyendra Pamecha 1, Nilesh Sadashiv Patil 2, Sanyam Falari 2, Nihar Mohapatra 2, Anubhav Harshit Kumar 2, Gaurav Sindwani 3, Neha Garg 3, Seema Alam 4, Rajeev Khanna 4, Vikrant Sood 4, Bikrant Bihari Lal 4

Abstract
Objective: This study aimed at studying the challenges and outcomes of live-donor liver transplantation (LDLT) for pediatric acute liver failure (PALF).
Study design: A total of 315 patients with PALF were treated over a period of 11 years. 42 underwent LT (41 LDLT and one DDLT), constituting 38% (41/110) of all pediatric transplants during this duration. The outcomes of LDLT for PALF were analyzed.

Results: All the 41 children who underwent LT met the Kings College criteria (KCC). The etiology was indeterminate in 46.3% (n = 19) children. 75.6% (n = 31) were on mechanical ventilation for grade 3/4 hepatic encephalopathy. There was presence of cerebral edema on a computed tomography scan of the brain in 50% of the children. One-third of our children required hemodynamic support with vasopressors. Systemic inflammatory response syndrome and sepsis were observed in 46.3% and 41.4% of patients, respectively. Post-LDLT 1- and 5-yr patient and graft survival were 75.6% and 70.9%, respectively. The survival in children satisfying KCC but did not undergo LT was 24% (38/161). Vascular and biliary complication rates were 2.4% and 4.8%, respectively. No graft loss occurred because of acute rejection. In multivariate analysis, pre-LT culture positivity and cerebral edema, persistence of brain edema after transplantation, and resultant pulmonary complications were significantly associated with post-LT death. Thirteen (32%) children who underwent plasmapheresis prior to LT had better post-LT neurological recovery, as evidenced by early extubation.

Conclusion: LDLT for PALF is lifesaving and provides a unique opportunity to time transplantation. Good long-term survival can be achieved, despite the majority of patients presenting late for transplantation. Early referral and better selection can save more lives through timely transplantation.