https://www.ncbi.nlm.nih.gov/pubmed/28374256

Öztürk M1, Akdulum İ2, Dağ N2, Sığırcı A2, Güngör S3, Yılmaz S4. Radiol Med. 2017 Aug;122(8):617-622. doi: 10.1007/s11547-017-0756-4. Epub 2017 Apr 3.

Abstract

OBJECTIVE:
To analyze the magnetic resonance imaging findings in children diagnosed with neurologic complications after liver transplantation (LT).

MATERIALS AND METHODS:
A total of 39 patients diagnosed with neurologic complications following LT between 2010 and 2016. Neuroradiologic imaging was performed using cranial magnetic resonance imaging (MRI). Descriptive statistics regarding age, gender, type of complication, diagnostic and therapeutic modalities were calculated and presented as number and percentage.

RESULTS:
Our series consisted of 18 girls and 21 boys. Cryptogenic hepatitis (n = 13, 32%), metabolic diseases (Wilson's disease, tyrosinemia and glycogen storage disease) (n = 7, 18%) and fulminant toxic hepatitis (n = 4, 11%) constitute the most frequent indications for LT. The indications for neuroradiological imaging were convulsion and alteration of mental status.

CONCLUSION:
These central nervous system complications may present in a variable spectrum and convulsions and altered mental state were the most frequent clinical pictures. Imaging studies were normal in approximately one-third of cases; the most frequent pathologic findings were diffuse cerebral edema, atrophy, and PRES. Clinical history, careful examination and integrated analysis of radiologic data as well as close collaboration and multidisciplinary approach are of utmost importance for establishing the diagnosis rapidly and accurately.