https://www.ncbi.nlm.nih.gov/pubmed/29471012 NAFLD

J Hepatol. 2018 Feb 19. pii: S0168-8278(18)30123-5. doi: 10.1016/j.jhep.2018.02.006. [Epub ahead of print]
.Hegarty R, Deheragoda M, Fitzpatrick E, Dhawan A.

Abstract
The recognition of a pattern of steatotic liver injury where histology mimicked alcoholic liver disease but alcohol consumption was denied, led to the identification of non-alcoholic fatty liver disease (NAFLD). Non-alcoholic fatty liver disease has since become the most common chronic liver disease in adults owing to the global epidemic of obesity. However, in pediatrics, the term NAFLD seems incongruous: alcohol consumption is largely not a factor and inherited metabolic disorders (IMD) can mimic or co-exist with a diagnosis of NAFLD. The term pediatric fatty liver disease (PeFLD) may be more appropriate. In this article, we summarise the known causes of steatosis in children according to their typical, clinical presentation: 1. acute liver failure 2. neonatal or infantile jaundice 3. hepatomegaly, splenomegaly or hepato-splenomegaly 4. developmental delay / psychomotor retardation and perhaps most commonly; 5. the asymptomatic child with incidental discovery of abnormal liver enzymes. We offer this model as a means to provide pathophysiological insights and an approach to management of the ever more complex subject of fatty liver. Lay summary Fatty liver disease caused by sedentary lifestyle is the most common long-term liver disease in adults today. Caution must be exercised when calling children with fatty liver disease as there may be hidden, genetically inherited problems with their metabolism.