https://www.ncbi.nlm.nih.gov/pubmed/29998462 Hepatic steatosis

Aliment Pharmacol Ther. 2018 Jul 11. doi: 10.1111/apt.14900. [Epub ahead of print]
Hepatic steatosis is highly prevalent across the paediatric age spectrum, including in pre-school age children.Dhaliwal J1,2, Chavhan GB2,3, Lurz E1,2, Shalabi A2,3, Yuen N2,3, Williams B1,2, Martincevic I1,2, Amirabadi A2,3, Wales PW2,4, Lee W2,3, Ling SC1,2, Mouzaki M5.

Abstract

BACKGROUND:
The prevalence of non-alcoholic fatty liver disease (NAFLD) in children is 8% in the general population, and 34% in the context of obesity. There is a paucity of data on the prevalence of hepatic steatosis in healthy children in Ontario.

AIMS:
To determine the prevalence of hepatic steatosis using abdominal computed tomography (CT) scans in a cohort of previously healthy children across the paediatric age spectrum in Ontario, Canada, and to determine association between measures of abdominal adiposity and hepatic steatosis.

METHODS:
Retrospective review of the SickKids Trauma Database from 2004-2015. Previously healthy children ages 1-17 years having undergone an abdominal CT scan as a part of routine trauma assessment were included, and those with an intra-abdominal injury excluded. Steatosis was defined as a difference between liver and spleen attenuation ≤-25HU. The percentage of the total area occupied by abdominal subcutaneous adipose and visceral adipose tissue was measured. Anthropometrics and baseline demographics were collected.

RESULTS:
A total of 503 (51% male) children with mean (±SD) age 9.5 ± 4.5 years and weight z-score of 0.37 ± 1.05 were studied. Seventy-seven (15%, 95% CI [12%-18%]) had hepatic steatosis; no differences found between sexes or across age quartiles. The abdominal subcutaneous adipose tissue area was greater in those with hepatic steatosis compared to those without (32% [22-42] vs 24% [17-36], P = 0.003). The visceral adipose tissue area was significantly greater in older children ≥9.8 years with hepatic steatosis (7.7% [5.1-10] vs 6.6% (4.9-8.5), P = 0.04).

CONCLUSION:
Hepatic steatosis was highly prevalent in previously healthy children in Ontario, including children of pre-school age. We found an association between hepatic steatosis and abdominal subcutaneous adipose tissue, and in older children with visceral adipose tissue.