https://www.ncbi.nlm.nih.gov/pubmed/30335007 NAFLD

Medicine (Baltimore). 2018 Oct;97(42):e12879. doi: 10.1097/MD.0000000000012879.
Nonalcoholic fatty liver disease with prolactin-secreting pituitary adenoma in an adolescent: A case report.
Takaki Y1, Mizuochi T, Nishioka J, Eda K, Yatsuga S, Yamashita Y.

Abstract

RATIONALE:
Nonalcoholic fatty liver disease (NAFLD), among the commonest chronic liver disorders in children and adolescents, is considered a reflection of the current obesity epidemic in children and adults. This liver disease has been linked with various metabolic disorders, but not with prolactinoma (PRLoma).

PATIENT CONCERNS:
A 13-year-old Japanese girl manifested obesity, serum transaminase and γ-glutamyltransferase elevations, and amenorrhea. Abdominal ultrasonography showed fatty liver. Her serum prolactin concentration was elevated, and cranial magnetic resonance imaging showed a pituitary mass consistent with macroadenoma.

DIAGNOSES:
NAFLD and PRLoma.

INTERVENTIONS AND OUTCOMES:
After the patient's NAFLD failed to respond to diet and exercise, cabergoline treatment of the PRLoma decreased body weight, serum transaminase and γ-glutamyltransferase elevations, and ultrasonographic fatty liver grade as the tumor became smaller.

LESSONS:
Physicians should consider the possibility of PRLoma when diet and exercise fail to improve fatty liver disease in a patient with endocrine symptoms such as amenorrhea.