https://www.ncbi.nlm.nih.gov/pubmed/31778017 Acute liver failure

Liver Transpl. 2019 Nov 28. doi: 10.1002/lt.25693. [Epub ahead of print]
Acute liver failure in children: is it time to revise the diagnostic criteria?
Di Giorgio A1, D'Antiga L1.

Author information

Abstract
Despite decades of research to improve the outcome of acute liver failure (ALF), there is still a very short time window to identify the etiology, start a specific treatment, and decide whether a liver transplant (LT) is needed in an individual patient. The etiology of ALF remains unknown in a large proportion of pediatric cases (1). ALF in children reflects a variety of causes, and the identification of etiology impacts management (2). Prompt distinction between those with known causes and the really indeterminate cases is crucial (3).