https://www.ncbi.nlm.nih.gov/pubmed/31831396
J Infect Public Health. 2019 Dec 9. pii: S1876-0341(19)30349-1. doi: 10.1016/j.jiph.2019.11.009. [Epub ahead of print]
Effects of Epstein-Barr virus infection on liver function in children.
Zhang Y1, Zhao Y1, Jiang Y1, Wang H2.

Abstract

OBJECTIVE:
In order to analyze the effect of Epstein-Barr (EB) virus infection on the liver function of children, the age and season of children susceptible to EB virus were analyzed in this study.

METHODS:
In this study, 118 children with EB infection from Cangzhou Central Hospital were selected as the subjects, and 10 children with normal liver function were selected as the control group. Compared with normal children, the changes of blood cells, immune cells and indicators related to liver function in patients with EB virus infection were compared, and the expression of EB virus -DNA in patients' peripheral blood was analyzed. Immunohistochemistry was used to analyze the location and changes of CD4+T lymphocytes, CD8+T lymphocytes, and granzyme B cells in the liver of the patients. And changes in liver tissue were studied by in situ hybridization.

RESULTS:
It was found that children in early childhood (1-3 years old) were the most susceptible group, and summer and autumn were the most susceptible seasons. Compared with normal children, the number of red blood cells and white blood cells in patients infected with EB virus increased, while the number of platelets decreased, but the difference was not significant. The liver function indexes of Alanine transaminase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), total bilirubin (TBIL), and lactate dehydrogenase (LDH) increased after infection. The content of CD4+T lymphocytes decreased, while that of CD8+T lymphocytes increased. The level of immune factor IgG increased significantly (P<0.01), granzyme B cells were positive compared to that of normal humans, and positive lymphocytes containing EBER appeared.

CONCLUSION:
Therefore, EB virus may affect liver function by acting CD8+T lymphocytes in children.