https://pubmed.ncbi.nlm.nih.gov/32437004/?from_term=children+AND+liver&f...

J Med Virol.2020 May 21.
doi: 10.1002/jmv.26036. Online ahead of print.

Hepatic Complications of COVID-19 and Its Treatment
Dandan Tian 1, Qing Ye 1

Abstract

COVID-19 is highly contagious and has a variety of clinical manifestations, it can affect a number of other organs in addition to the lungs, and liver injury may occur. SARS-CoV-2 can cause liver injury through systemic inflammatory response syndrome (SIRS), cytokine storms, ischemia-reperfusion injury, side effects of treatment drugs, and underlying liver disease and can attack liver cells directly via ACE2. Clinical studies have found that liver injury in COVID-19 patients mainly manifests as abnormal liver biochemical indicators, but there have been no reports of liver failure caused by this disease. The number of COVID-19 patients with liver injury is increasing, and the incidence of liver injury in COVID-19 patients with severe disease are higher than in patients with mild disease. Liver injury may be a risk factor for progresses and worsens in patients with COVID-19, and it is necessary to pay attention to the occurrence of liver injury in the diagnosis and treatment of COVID-19. This article is protected by copyright. All rights reserved.