https://pubmed.ncbi.nlm.nih.gov/32546255/ Hepatitis
BMC Pulm Med. 2020 Jun 16;20(1):173.
doi: 10.1186/s12890-020-01215-6.
Hepatitis in Children With Tuberculosis: A Case Report and Review of the Literature
Maria Sanchez-Codez 1, W Garret Hunt 2, Joshua Watson 2, Asuncion Mejias 3 4
PMID: 32546255

PMCID: PMC7298953

DOI: 10.1186/s12890-020-01215-6

Abstract

Background: Hepatitis in young children with tuberculosis (TB) outside miliary TB is not well described and represents a challenge because of the hepatotoxicity associated with first-line anti-TB treatment.

Case presentation: We report an antibiotic naïve 13-month-old male from Nepal with pulmonary TB and hepatitis, who improved after TB treatment. We also performed a literature review for TB-associated hepatitis in children.

Conclusions: Liver function tests should be considered, when feasible, in infants and young children with pulmonary TB. Testing could help to identify and manage patients with TB-associated hepatic abnormalities, and also to establish a baseline for detection and management of liver injury associated with anti-TB therapy.