https://pubmed.ncbi.nlm.nih.gov/33114650/

J Clin Med. 2020 Oct 26;9(11):E3435.
doi: 10.3390/jcm9113435.

Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries

Suk Kyun Hong 1, Nam-Joon Yi 1, Kyung Chul Yoon 1, Myoung Soo Kim 2, Jae Geun Lee 2, Sanghoon Lee 3, Koo Jeong Kang 4, Shin Hwang 5, Je Ho Ryu 6, Kwangpyo Hong 1, Eui Soo Han 1, Jeong-Moo Lee 1, Kwang-Woong Lee 1, Kyung-Suk Suh 1

Abstract

Background: This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Organ Transplantation Registry (KOTRY).

Methods: Prospectively collected data of 755 pediatric patients who underwent primary LT (KONOS, February 2000 to December 2015; KOTRY, May 2014 to December 2017) were retrospectively reviewed.

Results: The 1-, 5-, 10-, and 15-year survival rates were 90.6%, 86.7%, 85.8%, and 85.5%, respectively, in KONOS, and the 1-month, 3-month, 1-year, and 2-year survival rates were 92.1%, 89.4%, 89.4%, and 87.2%, respectively, in KOTRY. There was no significant difference in survival between the two registries. Multivariate analysis identified that body weight ≥6 kg (p <0.001), biliary atresia as underlying liver disease (p = 0.001), and high-volume center (p < 0.001) were associated with better survival according to the KONOS database, while hepatic artery complication (p < 0.001) was associated with poorer overall survival rates according to the KOTRY database.

Conclusion: Long-term pediatric patient survival after LT was satisfactory in this Korean national registry analysis. However, children with risk factors for poor outcomes should be carefully managed after LT.