https://pubmed.ncbi.nlm.nih.gov/34183614/ transplant
J Pediatr Gastroenterol Nutr. 2021 Jun 28.
doi: 10.1097/MPG.0000000000003213.Online ahead of print.

Acute liver injury among Pediatric Liver Transplantation recipients with COVID-19: An International Collaborative Study

Priscila Sin 1, Luis Antonio Díaz, Mercedes Martínez, Cecilia Vizcaya, Daniel D'Agostino, Juan Cristóbal Gana

Abstract
Coronavirus disease 2019 (COVID-19) is an ongoing pandemic. The occurrence of acute liver injury (ALI) has been reported in liver transplant (LT) recipients; however, the findings on children remain controversial. This is the first extensive, worldwide report on the impact of COVID-19 on pediatric LT recipients. Our online survey reported 110 pediatric LT recipients with SARS-CoV-2 infection. Of these, 37 were symptomatic and 20 out of them (54%) had complicated COVID-19, which included ALI and acute liver graft rejection. No mortality was reported. Pediatric LT recipients who had undergone transplantation less than 6 months prior to contracting COVID-19 had a greater number of hospital admissions and a higher ALI frequency (p = 0.013 and p = 0.033, respectively) than those who had undergone transplantation more than 6 months prior. Our study found that COVID-19 cases among pediatric LT recipients demonstrated a high complication rate. We propose that these patients must be followed up strictly.