https://pubmed.ncbi.nlm.nih.gov/34688573/ cholestasis

Review

Dig Liver Dis. 2021 Oct 20;S1590-8658(21)00780-5.
doi: 10.1016/j.dld.2021.09.011.Online ahead of print.

Diagnostic approach to neonatal and infantile cholestasis: A position paper by the SIGENP liver disease working group

Giusy Ranucci 1, Claudia Della Corte 2, Daniele Alberti 3, Maria Pia Bondioni 4, Giovanni Boroni 3, Pier Luigi Calvo 5, Mara Cananzi 6, Manila Candusso 2, Maria Grazia Clemente 7, Lorenzo D'Antiga 8, Irene Degrassi 9, Jean De Ville De Goyet 10, Fabiola Di Dato 11, Angelo Di Giorgio 8, Carlo Dionisi Vici 12, Federica Ferrari 13, Paola Francalanci 14, Maurizio Fuoti 15, Fabio Fusaro 16, Paola Gaio 6, Chiara Grimaldi 17, Maria Iascone 18, Giuseppe Indolfi 19, Raffaele Iorio 11, Giuseppe Maggiore 2, Claudia Mandato 1, Lorenza Matarazzo 20, Lidia Monti 21, Fabio Mosca 22, Gabriella Nebbia 9, Federica Nuti 9, Giulia Paolella 9, Michele Pinon 5, Paola Roggero 22, Marco Sciveres 23, Daniele Serranti 19, Marco Spada 17, Pietro Vajro 24, Emanuele Nicastro 8

Abstract

Neonatal and infantile cholestasis (NIC) can represent the onset of a surgically correctable disease and of a genetic or metabolic disorder worthy of medical treatment. Timely recognition of NIC and identification of the underlying etiology are paramount to improve outcomes. Upon invitation by the Italian National Institute of Health (ISS), an expert working grouped was formed to formulate evidence-based positions on current knowledge about the diagnosis of NIC. A systematic literature search was conducted to collect evidence about epidemiology, etiology, clinical aspects and accuracy of available diagnostic tests in NIC. Evidence was scored using the GRADE system. All recommendations were approved by a panel of experts upon agreement of at least 75% of the members. The final document was approved by all the panel components. This position document summarizes the collected statements and defines the best-evidence diagnostic approach to cholestasis in the first year of life.