https://pubmed.ncbi.nlm.nih.gov/34808224/ NAFLD

J Pediatr. 2021 Nov 19;S0022-3476(21)01114-8.
doi: 10.1016/j.jpeds.2021.11.042.Online ahead of print.

Comparison of Triglyceride Glucose (TyG) Index and Modified TyG Indices to Predict Non-Alcoholic Fatty Liver Disease in Youth

Kyungchul Song 1, Goeun Park 2, Hye Sun Lee 2, Myeongseob Lee 1, Hae In Lee 1, Han Saem Choi 1, Junghwan Suh 1, Ahreum Kwon 1, Ho-Seong Kim 1, Hyun Wook Chae 3

Abstract

Objective: To assess the association of the triglyceride glucose (TyG) and modified TyG indices with non-alcoholic fatty liver disease (NAFLD) and their abilities as predictors of NAFLD in the youth.

Study design: We analyzed the cross-sectional data of 3,728 individuals aged 10-19 years using the Korea National Health and Nutrition Examination Survey, a nationally representative survey. Logistic regression analysis was performed, and odds ratios (ORs) and 95% confidence intervals (CIs) of tertiles 2 and 3 for each variable for predicting NAFLD were calculated and compared with those of tertile 1 for reference. Receiver operating characteristic curves were plotted to evaluate the ability of each variable for NAFLD prediction.

Results: All TyG and modified TyG indices exhibited progressively increased ORs and 95% CIs for NAFLD across all tertiles (all P < .001). In addition, all TyG and modified TyG indices significantly predicted NAFLD through receiver operating characteristic curves. All modified TyG indices were superior to the TyG index for predicting NAFLD in all subjects and in males. Among females, the TyG-waist-to-height ratio was superior to the TyG index, TyG-body mass index, and TyG-waist circumference, and the TyG-body mass index standard deviation score and TyG-waist circumference were superior to the TyG index.

Conclusions: The TyG and modified TyG indices are markers for NAFLD prediction in the youth. Moreover, modified TyG indices were superior to the TyG index. Modified TyG indices have the potential to be simple and cost-effective markers for the screening of NAFLD in the youth.