https://pubmed.ncbi.nlm.nih.gov/35131781/ Wilson

BMJ Case Rep. 2022 Feb 7;15(2):e246075.
doi: 10.1136/bcr-2021-246075.

Hyperpigmented patch: an uncommon but early marker of Wilson's disease

Lokesh Tiwari 1, Fadila 2, Arnab Ghorui 2

Abstract

Wilson's disease in childhood could present with features ranging from asymptomatic liver disease to acute liver failure and cirrhosis. Neurological manifestations and psychiatric illness occur more commonly in adults and older children. Skin manifestation with Wilson's disease is not frequently reported in literature but could be an early diagnostic clincher. We present a child with hepatic Wilson's disease and skin hyperpigmentation. We aim to highlight the possible importance of skin lesions as an early marker of Wilson's disease.