https://pubmed.ncbi.nlm.nih.gov/35758473/ NAFLD

J Pediatr Gastroenterol Nutr. 2022 Jun 27.
doi: 10.1097/MPG.0000000000003537.Online ahead of print.
The benefit of probiotics in pediatric non-alcoholic fatty liver disease: a meta-analysis of randomized control trials

Νikolaos Gkiourtzis 1 2, Georgios Kalopitas 3, Andreas Vadarlis 3 4, Dimitra Rafailia Bakaloudi 2, Georgios Dionysopoulos 2, Evangelia Karanika 2, Eirini Tsekitsidi 2, Michail Chourdakis 2

Abstract

Objectives: We conducted a systematic review and meta-analysis to provide a summary of the current literature about the efficacy of probiotics in pediatric non-alcoholic fatty liver disease (NAFLD).

Methods: A systematic literature search through major electronic databases was carried out for RCTs till September 9th, 2021, investigating the efficacy of probiotics in the treatment of pediatric patients with NAFLD. Weighted mean differences (WMD) and Standard Deviations (SD) were used to calculate continuous outcomes and a Risk Ratio with 95% CI was used for dichotomous outcomes.

Results: In total, 4 RCTs with 238 pediatric patients with NAFLD were included in the study. Probiotic supplementation revealed a statistically significant difference in transaminases' levels [(ALT: WMD=-7.51 IU/L, 95% CI:-11.28 to -3.73, I2=0%, p<0.0001), (AST: WMD=-6.46 IU/L, 95% CI:-9.31 to -3.61, I2=0%, p<0.00001)], anthropometric characteristics, total cholesterol, triglycerides and ultrasonographic steatosis improvement.

Conclusions: According to the data of this meta-analysis, probiotic supplementation, and especially supplementation of Lactobacillus acidophilus in combination with other strains of Bifidobacterium or Lactobacillus may be beneficial in the improvement of transaminases', lipid parameters' levels, ultrasonographic and anthropometric characteristics in children with NAFLD. Current evidence does not allow specifying the exact beneficial strain of probiotics mentioned above. The possible effect of probiotics on liver histology improvement in pediatric NAFLD should be examined in future studies.

Published on: 
Jun-2022

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