https://pubmed.ncbi.nlm.nih.gov/36010027/ drug induced hepatitis

Children (Basel). 2022 Jul 29;9(8):1136.
doi: 10.3390/children9081136.

Drug-Induced Hepatitis in Children: The Experience of a Single Center in Romania

Irina Dijmărescu 1 2, Oana Maria Guță 1, Livia Elena Brezeanu 1, Adrian Dumitru Dijmărescu 3, Cristina Adriana Becheanu 1 2, Daniela Păcurar 1 2
Affiliations expand
PMID: 36010027

PMCID: PMC9406845

DOI: 10.3390/children9081136
Free PMC article
Abstract

Drug-induced liver injury (DILI) is uncommon but potentially lethal. Over 6 years, 2533 children with acute liver disease were identified in our center, 48 of which suffered from toxic hepatitis, and 40 exhibited DILI (22 paracetamol-related, 14 albendazole-related). The most affected children were in the 13-17-year-old age group. The mean time between drug ingestion and disease diagnosis was 25.4 h for paracetamol-related DILI and 21.6 days for the albendazole-related group. Clinical features were mostly gastrointestinal, jaundice being reported in 30% of the cases. Regarding the type of liver injury, for 70% of the patients it was hepatocellular (mostly paracetamol toxicity), for 11% cholestatic, and for 19% mixed (albendazole-related). The mean initial ALT value was 1020 U/L for all DILIs. Coagulopathy was only identified for the acetaminophen-related group. The median number of hospitalization days was 6.9 for DILI related to acetaminophen ingestion, compared with 7 for the idiosyncratic pattern. When applying the DILI severity index, 81% of the patients were categorized as having a mild hepatic ailment, while 19% had a moderate-severe or severe disease. No deaths were reported in the study group. The diagnosis of DILI involves the exclusion of other causes of liver injury; therefore, it is considered one of the most challenging diagnoses in hepatology.

Published on: 
Aug-2022

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