https://pubmed.ncbi.nlm.nih.gov/36694298/ Liver transplant

Case Reports

Pediatr Transplant. 2023 Jan 24;e14473.
doi: 10.1111/petr.14473. Online ahead of print.

Late airway complications following pediatric liver transplantation: A case series
Vivek Rajasekaran 1 2, Craig McCaffer 3, Jonathan Bishop 1, Graeme Van Der Meer 3, Edward C Toll 3, Helen Evans 1 2

Abstract
Background: Late airway complications, as consequence of immunosuppression following pediatric liver transplantation are uncommonly reported.

Methods: In this retrospective case series, we describe two young children presenting with symptoms of airway obstruction, secondary to differing pathologies in the supraglottic airway, as a result of immunosuppression following liver transplantation.

Results: Case 1, a 2-year-old girl who presented with stridor 12-months following liver transplantation, was found to have a proliferative soft tissue mass involving the supraglottic larynx. Biopsies were consistent with infiltrative eosinophilic laryngitis and associated eosinophilic esophagitis. Case 2, a 12-month-old female who presented with stridor 5-months following liver transplantation, was found to have an exophytic soft tissue mass involving the supraglottis and hypopharynx. Biopsies revealed polymorphic Epstein-Barr virus (EBV) driven post-transplant lymphoproliferative disease (PTLD). Case 1 was managed with local resection and high dose oral corticosteroids. Case 2 responded to debulking of the necrotic supraglottic mass, reduction of immunosuppression and rituximab.

Conclusion: A high index of suspicion needs to be maintained for complications of immunosuppression for appropriate diagnosis of airway presentations following pediatric liver transplantation. Further research is necessary to improve early detection and consolidate management strategies for these airway lesions.