https://pubmed.ncbi.nlm.nih.gov/38010711/ transplant

Transpl Infect Dis. 2023 Nov 27:e14200.
doi: 10.1111/tid.14200. Online ahead of print.

Impact of preoperative bloodstream infection on outcomes of pediatric liver transplant recipients treated for acute liver failure

Chiaki Baba 1 2, Takanori Funaki 3, Makoto Uranaka 1, Mai Hashiya 1, Jun Ninagawa 1, Seisuke Sakamoto 4, Mureo Kasahara 4, Yasuko Nagasaka 2, Yasuyuki Suzuki 1 2, Shugo Kasuya 1

Abstract

Background: Acute liver failure (ALF) is a component of multisystem organ failure that causes severe liver dysfunction in patients without underlying chronic liver disease. The patients with ALF are prone to have infections, including bacteremia. However, studies of the infectious impact for post liver transplantation (LT) in pediatric ALF are limited. We aimed to evaluate our current practice for pediatric LT cases of ALF with preoperative bacteremia.

Methods: The records of all patients under 18 years old undergoing LT for ALF in our center from November 2005 to December 2021 were collected. They were divided into two groups: those with a preoperative bloodstream infection (BSI) and those without (NBSI). We compared the preoperative status and also reviewed the details of the BSI group. Intraoperative course and postoperative outcomes were also compared.

Results: There were 19 BSI patients and 66 NBSI patients. One BSI case was detected on the day of LT. This patient had no changes in vital signs and general condition. After evaluation and therapeutic intervention by pediatric infectious disease specialists, LT was performed on the same day. Five cases developed septic shock at the time of detection of BSI. All BSI patients were in stable condition on the operation day with proper interventions. There were no significant differences in mortality and hospital stay between both groups.

Conclusions: LT might be able to be performed for pediatric ALF even with positive blood cultures. In addition, appropriate therapeutic intervention by specialists and patient's stable condition before LT are essential.