https://pubmed.ncbi.nlm.nih.gov/38681989/ NAFLD

Editorial

World J Gastroenterol. 2024 Apr 21;30(15):2081-2086.
doi: 10.3748/wjg.v30.i15.2081.

Interplay between metabolic dysfunction-associated fatty liver disease and renal function: An intriguing pediatric perspective

Michele Nardolillo 1, Fabiola Rescigno 1, Mario Bartiromo 1, Dario Piatto 1, Stefano Guarino 1, Pierluigi Marzuillo 1, Emanuele Miraglia Del Giudice 1, Anna Di Sessa 2
Affiliations expand
PMID: 38681989

PMCID: PMC11045477

DOI: 10.3748/wjg.v30.i15.2081
Abstract
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Over recent years, the nomenclature of non-alcoholic fatty liver disease has undergone significant changes. Indeed, in 2020, an expert consensus panel proposed the term "Metabolic (dysfunction) associated fatty liver disease" (MAFLD) to underscore the close association of fatty liver with metabolic abnormalities, thereby highlighting the cardiometabolic risks (such as metabolic syndrome, type 2 diabetes, insulin resistance, and cardiovascular disease) faced by these patients since childhood. More recently, this term has been further replaced with metabolic associated steatotic liver disease. It is worth noting that emerging evidence not only supports a close and independent association of MAFLD with chronic kidney disease in adults but also indicates its interplay with metabolic impairments. However, comparable pediatric data remain limited. Given the progressive and chronic nature of both diseases and their prognostic cardiometabolic implications, this editorial aims to provide a pediatric perspective on the intriguing relationship between MAFLD and renal function in childhood.