https://pubmed.ncbi.nlm.nih.gov/39212863/ Acute liver failure

Editorial

Hepatol Int. 2024 Aug 30.
doi: 10.1007/s12072-024-10720-3. Online ahead of print.

Diagnosis and management of pediatric acute liver failure: consensus recommendations of the Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN)

Bikrant Bihari Lal 1, Rajeev Khanna 1, Vikrant Sood 1, Seema Alam 2, Aabha Nagral 3 4, Aathira Ravindranath 5, Aditi Kumar 6, Akash Deep 7, Amrit Gopan 8, Anshu Srivastava 9, Arjun Maria 10, Arti Pawaria 11, Ashish Bavdekar 12, Gaurav Sindwani 13, Kalpana Panda 14, Karunesh Kumar 15, Malathi Sathiyasekaran 16, Maninder Dhaliwal 17, Marianne Samyn 18, Maya Peethambaran 19, Moinak Sen Sarma 9, Moreshwar S Desai 20, Neelam Mohan 21, Nirmala Dheivamani 22, Piyush Upadhyay 23, Pratibha Kale 24, Rakhi Maiwall 25, Rohan Malik 26, Roshan Lal Koul 27, Snehavardhan Pandey 28, Somashekara Hosaagrahara Ramakrishna 29, Surender Kumar Yachha 30, Sadhna Lal 31, Sahana Shankar 32, Sajan Agarwal 33, Shivani Deswal 34, Smita Malhotra 35, Vibhor Borkar 36, Vipul Gautam 37, Viswanathan M Sivaramakrishnan 38, Anil Dhawan 18, Mohamed Rela 39, Shiv Kumar Sarin 25
Affiliations expand
PMID: 39212863

DOI: 10.1007/s12072-024-10720-3
Abstract

Timely diagnosis and management of pediatric acute liver failure (PALF) is of paramount importance to improve survival. The Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition invited national and international experts to identify and review important management and research questions. These covered the definition, age appropriate stepwise workup for the etiology, non-invasive diagnosis and management of cerebral edema, prognostic scores, criteria for listing for liver transplantation (LT) and bridging therapies in PALF. Statements and recommendations based on evidences assessed using the modified Grading of Recommendations Assessment, Development and Evaluation (GRADE) system were developed, deliberated and critically reappraised by circulation. The final consensus recommendations along with relevant published background information are presented here. We expect that these recommendations would be followed by the pediatric and adult medical fraternity to improve the outcomes of PALF patients.