Event Videos

https://pubmed.ncbi.nlm.nih.gov/34448327/ liver transplant

Review

Pediatr Transplant. 2021 Aug 27;e14114.
doi: 10.1111/petr.14114.Online ahead of print.
Domino transplantation for pediatric liver recipients: Obstacles, challenges, and successes
Vikram K Raghu 1, Peter D Carr-Boyd 2, James E Squires 1, Jerry Vockley 3, Nicolas Goldaracena 4, George V Mazariegos 2

Abstract

Published on: 
Aug-2021

https://pubmed.ncbi.nlm.nih.gov/34461848/ Hepatitis A

BMC Infect Dis. 2021 Aug 30;21(1):890.
doi: 10.1186/s12879-021-06594-7.

Clinical characteristics of acute liver failure associated with hepatitis A infection in children in Mogadishu, Somalia: a hospital-based retrospective study

Esra Keles 1, Mohamed A Hassan-Kadle 2 3, Marian Muse Osman 4, Hasan Huseyin Eker 5, Zeynep Abusoglu 6, Kursad Nuri Baydili 7, Aamir Muse Osman 8

Abstract

Published on: 
Aug-2021

https://pubmed.ncbi.nlm.nih.gov/34455394/ Biliary Atresia

EBioMedicine. 2021 Aug 26;71:103530.
doi: 10.1016/j.ebiom.2021.103530. Online ahead of print.

Identification of a wide spectrum of ciliary gene mutations in nonsyndromic biliary atresia patients implicates ciliary dysfunction as a novel disease mechanism

Wai-Yee Lam 1, Clara Sze-Man Tang 1, Man-Ting So 2, Haibing Yue 2, Jacob Shujui Hsu 3, Patrick Ho-Yu Chung 2, John M Nicholls 4, Fanny Yeung 2, Chun-Wai Davy Lee 5, Diem Ngoc Ngo 6, Pham Anh Hoa Nguyen 6, Hannah M Mitchison 7, Dagan Jenkins 7, Christopher O'Callaghan 8, Maria-Mercè Garcia-Barceló 2, So-Lun Lee 9, Pak-Chung Sham 3, Vincent Chi-Hang Lui 10, Paul Kwong-Hang Tam 11

Abstract

Published on: 
Aug-2021

https://pubmed.ncbi.nlm.nih.gov/34430430/

Transl Pediatr. 2021 Jul;10(7):1825-1833.
doi: 10.21037/tp-21-103.
PEX26 gene genotype-phenotype correlation in neonates with Zellweger syndrome

Yue He 1, Sam Bill Lin 1, Wen-Xuan Li 1, Lin Yang 2, Rong Zhang 1, Chao Chen 1, Lin Yuan 1

Abstract
Background: Zellweger syndrome (ZS) is commonly manifested as facial deformities, hypotonia, and liver dysfunction. However, ZS caused by PEX26 gene mutation shows a broad and dispersed clinical pattern. In this study, the PEX26 gene in ZS was analyzed to enrich its clinical characteristics. Meanwhile, phenotypic and genotypic characteristics of Zellweger spectrum disorder (ZSD) induced by PEX26 mutation were evaluated.

Published on: 
Aug-2021

https://pubmed.ncbi.nlm.nih.gov/34454951/ NAFLD

J Pediatr. 2021 Aug 26;S0022-3476(21)00826-X.
doi: 10.1016/j.jpeds.2021.08.041.Online ahead of print.

Prevalence and Clinical Significance of Autoantibodies in Children with Overweight and Obesity with Non-Alcoholic Fatty Liver Disease

Ammar Khayat 1, Bernadette Vitola 2

Abstract

Objectives: To evaluate the prevalence and clinical significance of autoantibodies in children with overweight and obesity with non-alcoholic fatty liver (NAFL), and non-alcoholic steatohepatitis (NASH) in comparison with those with autoimmune liver disease (ALD).

Published on: 
Aug-2021

https://pubmed.ncbi.nlm.nih.gov/34398413/ Transplant

Indian J Pediatr. 2021 Aug 16.
doi: 10.1007/s12098-021-03826-1. Online ahead of print.

Liver Transplantation: A Safe and Definitive Alternative to Lifelong Nitisinone for Tyrosinemia Type 1

Jagadeesh Menon 1, Naresh Shanmugam 2, Joseph J Valamparampil 1, Abdul Hakeem 3, Mukul Vij 4, Anil Jalan 5, Mettu Srinivas Reddy 3, Mohamed Rela 3 6

Abstract

Objectives: To report the experience of liver transplantation (LT) for tyrosinemia type 1 (TT-1).

Methods: Clinical data of children with TT-1 who underwent living donor LT between July 2009 and May 2020 were retrospectively analyzed. Data included pre-LT nitisinone therapy, graft type, post-LT complications, HCC incidence, and graft/patient survival.

Published on: 
Aug-2021

https://pubmed.ncbi.nlm.nih.gov/34452383/ hepatitis c

Viruses. 2021 Jul 31;13(8):1518.
doi: 10.3390/v13081518.

One-Year Outcomes after Ledipasvir/Sofosbuvir Treatment of Chronic Hepatitis C in Teenagers with and without Significant Liver Fibrosis-A Case Series Report

Maria Pokorska-Śpiewak 1 2, Anna Dobrzeniecka 2, Magdalena Marczyńska 1 2

Abstract

Published on: 
Aug-2021

https://pubmed.ncbi.nlm.nih.gov/34392560/ Biliary atresia

Hepatology. 2021 Aug 15.
doi: 10.1002/hep.32107. Online ahead of print.

Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia

Surya P Amarachintha 1, Reena Mourya 1, Hiroaki Ayabe 1, Li Yang 1, Zhenhua Luo 2, Xiaofeng Li 3, Unmesha Thanekar 1, Pranavkumar Shivakumar 1 4, Jorge A Bezerra 1 4

Abstract
Background & aims: Biliary atresia is a severe inflammatory and fibrosing cholangiopathy of neonates of unknown etiology. The onset of cholestasis at birth implies a prenatal onset of liver dysfunction.

Aim: To investigate the mechanisms linked to abnormal cholangiocyte development.

Published on: 
Aug-2021

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