Event Videos

https://pubmed.ncbi.nlm.nih.gov/33038344/

J Pediatr. 2020 Oct 7;S0022-3476(20)31260-9.
doi: 10.1016/j.jpeds.2020.09.068.Online ahead of print.

Fish Oil Emulsion Reduces Liver Injury and Liver transplantation in Children with Intestinal Failure-Associated Liver Disease: A Multicenter Integrated Study

Kathleen M Gura 1, Muralidhar H Premkumar 2, Kara L Calkins 3, Mark Puder

Objective: To compare aminotransferase with platelet ratio index (APRI), liver transplantation, and mortality rates between children with intestinal failure-associated liver disease (IFALD) who received fish oil lipid emulsion (FOLE) or soybean oil lipid emulsion (SOLE).

Published on: 
Oct-2020

https://pubmed.ncbi.nlm.nih.gov/33069290/ Hemangioma
Semin Pediatr Surg. 2020 Oct;29(5):150970.
doi: 10.1016/j.sempedsurg.2020.150970.Epub 2020 Sep 16.

Pediatric hepatic vascular tumors

Anna McGuire 1, Israel Fernandez-Pineda 2, Steven J Fishman 1, Belinda Hsi Dickie 3

Abstract

Vascular liver tumors in the pediatric population can present a diagnostic dilemma. The most common hepatic vascular tumors are hepatic hemangiomas; however the differential diagnosis can also include other benign lesions and malignant masses. Management is unique to the type and nature of the specific lesion. Thus, correct diagnosis and timely intervention is critical. The work up, diagnosis, and management of the different hepatic lesions are discussed in this paper.

Published on: 
Oct-2020

https://pubmed.ncbi.nlm.nih.gov/33075013/ Cholestasis

J Pediatr Gastroenterol Nutr. 2020 Oct 16.
doi: 10.1097/MPG.0000000000002926.Online ahead of print.
Cholestasis Due to USP53 Deficiency
Laura N Bull 1, Rebecca Ellmers 2, Pierre Foskett 2, Sandra Strautnieks 2, Melissa Sambrotta 3, Piotr Czubkowski 4, Irena Jankowska 4, Bart Wagner 5, Maesha Deheragoda 2, Richard J Thompson 2 3

Abstract

Objectives: While a number of genetic forms of cholestasis have been identified, the genetic etiology of disease remains unidentified in a subset of cholestasis patients.

Published on: 
Oct-2020

https://pubmed.ncbi.nlm.nih.gov/33015834/ Liver transplant

Med J Aust. 2020 Oct 4.
doi: 10.5694/mja2.50802. Online ahead of print.

Outcomes for children after second liver transplantations are similar to those after first transplantations: a binational registry analysis

Angus W Jeffrey 1, Gary P Jeffrey 1 2, Michael Stormon 3 4, Gordon Thomas 3 4, Edward O'Loughlin 3 4, Albert Shun 3 4, Winita Hardikar 5, Robert Jones 6 7, John McCall 8 9, Helen Evans 9, Graham Starkey 6 7, Peter Hodgkinson 10 11, Looi C Ee 12, David Moore 13, Catherine Mews 14, Geoff W McCaughan 15 16, Peter W Angus 6 7, Alan J Wigg 17, Michael Crawford 4 15, Jonathan Fawcett 10

Published on: 
Oct-2020

https://pubmed.ncbi.nlm.nih.gov/32963496/ NAFLD

Mediators Inflamm. 2020 Sep 10;2020:8327945.

Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Peripheral Blood Leukocytes and Plasma of Children with Nonalcoholic Fatty Liver Disease

Joanna B Trojanek 1, Jacek Michałkiewicz 1 2, Renata Grzywa-Czuba 1, Wojciech Jańczyk 3, Lidia Gackowska 2, Izabela Kubiszewska 2, Anna Helmin-Basa 2, Aldona Wierzbicka-Rucińska 4, Mieczysław Szalecki 5 6, Piotr Socha 3

PMID: 32963496

Abstract

Published on: 
Sep-2020

https://pubmed.ncbi.nlm.nih.gov/32767607/ NAFLD

J Paediatr Child Health. 2020 Oct;56(10):1590-1596.
doi: 10.1111/jpc.15038. Epub 2020 Aug 7.

High prevalence of elevated serum liver enzymes in Chinese children suggests metabolic syndrome as a common risk factor

Jinling Wang 1, Hui-Qi Qu 2, Ke Huang 1, Wei Wu 1, Chunlin Wang 3, Li Liang 3, Chunxiu Gong 4, Feng Xiong 5, Feihong Luo 6, Geli Liu 7, Shaoke Chen 8, Lifeng Tian 2, Hakon Hakonarson 2 9, Junfen Fu 1

Abstract

Aim: This study investigated the pattern of liver enzymes in a large cohort of Chinese children and adolescents, including 16 383 individuals aged 4-18 years old recruited at six medical centres in China.

Published on: 
Oct-2020

https://pubmed.ncbi.nlm.nih.gov/31810868/ NAFLD

Clin Res Hepatol Gastroenterol. 2020 Sep;44(4):513-523.

Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model

Ming Ma 1, Qi Long 2, Fei Chen 2, Ting Zhang 2, Wenqiao Wang 2
PMID: 31810868

Abstract

Objective: Non-alcoholic fatty liver disease (NAFLD) refers to an accumulation of excess fat in liver due to causes other than alcohol use. The relationship between vitamin D (VD) and NAFLD has been previously studied. Therefore, we aimed to explore the mechanism involved active VD regulating the progression of NAFLD by inhibiting cell senescence and to provide a potential approach for further nutritional treatment of NAFLD.

Published on: 
Sep-2020

https://pubmed.ncbi.nlm.nih.gov/33023552/ Liver transplant
Case Reports

BMC Surg. 2020 Oct 6;20(1):224.
doi: 10.1186/s12893-020-00878-6.

Pediatric liver transplantation and COVID-19: a case report
Hamed Nikoupour 1, Kourosh Kazemi 1, Peyman Arasteh 1, Saba Ghazimoghadam 2, Hesameddin Eghlimi 1, Naghi Dara 3, Siavash Gholami 1, Saman Nikeghbalian 1

Background: Immunosuppressed patients, including individuals with organ transplantation, have been among susceptible groups with regard to COVID-19, on the other hand pediatric patients more commonly undergo a mild clinical course after acquiring COVID-19. To the best of the authors knowledge, to this date very little data exists on COVID-19 in a pediatric patient with liver transplantation.

Published on: 
Oct-2020

https://pubmed.ncbi.nlm.nih.gov/32145139/ NAFLD

BJOG.2020 Sep;127(10):1200-1209.

Overweight and obesity status from the prenatal period to adolescence and its association with non-alcoholic fatty liver disease in young adults: cohort study
A Cantoral 1, A Montoya 1, L Luna-Villa 1, E A Roldán-Valadez 2 3, M Hernández-Ávila 4, D Kershenobich 5, W Perng 6, K E Peterson 7 8 9, H Hu 9 10, J A Rivera 1, M M Téllez-Rojo 1

PMID: 32145139

Abstract

Objective: To examine the associations of maternal and child overweight status across multiple time-points with liver fat content in the offspring during young adulthood.

Design: Cohort study.

Setting: ELEMENT Cohort in Mexico City.

Population: Pregnant women with singleton births (n = 97).

Published on: 
Sep-2020

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