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Health utility and quality of life in pediatric liver transplant recipients https://www.ncbi.nlm.nih.gov/pubmed/32336002 Transplant Pediatr Transplant. 2020 Apr 26:e13720. doi: 10.1111/petr.13720. [Epub ahead of print] Health utility and quality of life in pediatric liver transplant recipients. Bharij A1, Neighbors K1, Alonso EM1, Mohammad S1. Abstract Published on: Apr-2020 Read more	Clinical profiles and diagnostic challenges in 1158 children with rare hepatobiliary disorders https://www.ncbi.nlm.nih.gov/pubmed/32289814 Pediatr Res. 2020 Apr 12. doi: 10.1038/s41390-020-0888-4. [Epub ahead of print] Clinical profiles and diagnostic challenges in 1158 children with rare hepatobiliary disorders. Dong Y1, Wang J2, Zhu S1, Zheng H3, Wang C4, Zhao P5. Abstract BACKGROUND: Diagnosis of rare diseases possesses a great challenge in pediatric hepatology because expert knowledge in the field is extremely insufficient. The study aims to explore new findings and collect diagnostic experience from pediatric rare liver diseases. METHODS: The large-sample case analysis study included pediatric patients who had liver-involved rare diseases. All cases underwent liver biopsy and/or gene sequencing. RESULTS: Published on: Apr-2020 Read more
Improving the Predictive Ability of the Pediatric End-Stage Liver Disease Score for Young Children Awaiting Liver Transplant https://www.ncbi.nlm.nih.gov/pubmed/32306489 Liver transplant Am J Transplant. 2020 Apr 19. doi: 10.1111/ajt.15925. [Epub ahead of print] Improving the Predictive Ability of the Pediatric End-Stage Liver Disease Score for Young Children Awaiting Liver Transplant. Hsu E1, Schladt DP2, Wey A2, Perito ER3, Israni AK2,4,5. Abstract Published on: Apr-2020 Read more	Trimethoprim-Sulfamethoxazole Associated Drug-Induced Liver Injury in Pediatrics: A Systematic Review https://www.ncbi.nlm.nih.gov/pubmed/32282528 Drug induced Pediatr Infect Dis J. 2020 Apr 8. doi: 10.1097/INF.0000000000002664. [Epub ahead of print] Trimethoprim-Sulfamethoxazole Associated Drug-Induced Liver Injury in Pediatrics: A Systematic Review. Burgos RM1, Reynolds KM2, Williams J2, Li W2, Yan CH2. Abstract BACKGROUND: Drug-induced liver injury (DILI) is a rare but known adverse event associated with trimethoprim-sulfamethoxazole (TMP-SMX) in adults. No studies to date have looked at the risk of this association in children. We systematically reviewed the evidence for a potential association between TMP-SMX and DILI in the pediatric population. METHODS: Published on: Apr-2020 Read more
Mutations in Myosin 5B (MYO5B) in Children with Early Onset Cholestasis https://www.ncbi.nlm.nih.gov/pubmed/32304554 Cholestasis J Pediatr Gastroenterol Nutr. 2020 Apr 16. doi: 10.1097/MPG.0000000000002740. [Epub ahead of print] Mutations in Myosin 5B (MYO5B) in Children with Early Onset Cholestasis. Cockar I1, Foskett P2, Strautnieks S2, Clinch Y2, Fustok J2, Rahman O2, Sutton H1,3, Mtegha M4, Fessatou S5, Kontaki E5, Papaevangelou V5, Deheragoda M2, Thompson RJ1,3, Grammatikopoulos T1,3. Abstract OBJECTIVES: Published on: Apr-2020 Read more	Revision of serum ALT upper limits of normal facilitates assessment of mild liverinjury in obese children with non-alcoholic fatty liver disease https://www.ncbi.nlm.nih.gov/pubmed/32267017 NAFLD J Clin Lab Anal. 2020 Apr 8:e23285. doi: 10.1002/jcla.23285. [Epub ahead of print] Revision of serum ALT upper limits of normal facilitates assessment of mild liverinjury in obese children with non-alcoholic fatty liver disease. Lu Y1,2,3, Wang Q1,2,3, Yu L1,2,3, Yin X1,2,3, Yang H1,2,3, Xu X1,2,3, Xia Y1,2,3, Luo Y4, Peng Y2,3, Yu Q5, Chen Z1, Yu J1, Lai M1, Wu N6, Pan XB7, Zheng X1,2,3. Abstract BACKGROUND: The serum alanine aminotransferase (ALT) level is a critical parameter for evaluating liver injury in non-alcoholic fatty liver disease (NAFLD). However, the currently accepted upper limits of normal (ULN) for serum ALT (ULN-ALT) are debated, as they may be excessively high. METHODS: Published on: Apr-2020 Read more
Liver resection for a congenital intrahepatic portosystemic shunt in a child with hyperammonemia and hypermanganesemia: a case report https://www.ncbi.nlm.nih.gov/pubmed/32303849 Surg Case Rep. 2020 Apr 17;6(1):73. doi: 10.1186/s40792-020-00838-5. Liver resection for a congenital intrahepatic portosystemic shunt in a child with hyperammonemia and hypermanganesemia: a case report. Takama Y1,2, Nakamura T3, Santo K3, Yoneda A3. Abstract BACKGROUND: Congenital portosystemic shunt (CPSS) is a rare malformation that leads to hyperammonemia, hypermanganesemia, and various symptoms. CPSSs are divided into intrahepatic and extrahepatic shunts. In patients with persistent CPSS including an intrahepatic portosystemic shunt (IPSS), early intervention to occlude the shunt reverses the associated complications. CASE PRESENTATION: Published on: Apr-2020 Read more	Ornithine Transcarbamylase Deficiency Presenting as Acute Liver Failure in Girls: A Paediatric Case Series. https://www.ncbi.nlm.nih.gov/pubmed/32265410 Metabolic J Pediatr Gastroenterol Nutr. 2020 Apr 3. doi: 10.1097/MPG.0000000000002716. [Epub ahead of print] Ornithine Transcarbamylase Deficiency Presenting as Acute Liver Failure in Girls: A Paediatric Case Series. Selvanathan A1,2, Hertzog A3, Lemberg DA4,5, Ellaway C6,7. Abstract Published on: Apr-2020 Read more
Clinical risk stratification of children with SIOPEL high-risk hepatoblastoma in Taiwan https://www.ncbi.nlm.nih.gov/pubmed/32291200 Hepatoblastoma Pediatr Neonatol. 2020 Mar 24. pii: S1875-9572(20)30052-8. doi: 10.1016/j.pedneo.2020.03.012. [Epub ahead of print] Clinical risk stratification of children with SIOPEL high-risk hepatoblastoma in Taiwan. Hsu WY1, Chang HH2, Lu MY3, Yang YL4, Jou ST5, Chen HL6, Ni YH7, Hsu HY8, Chang MH9, Wu JF10. Abstract BACKGORUND: Hepatoblastoma is the most common primary liver malignancy in young children. METHODS: Published on: Apr-2020 Read more	Hepatic Histology in Treatment-naïve Children With Chronic Hepatitis B Infection Living in the United States and Canada. https://www.ncbi.nlm.nih.gov/pubmed/32265408 Hepatitis B J Pediatr Gastroenterol Nutr. 2020 Apr 3. doi: 10.1097/MPG.0000000000002712. [Epub ahead of print] Hepatic Histology in Treatment-naïve Children With Chronic Hepatitis B Infection Living in the United States and Canada. Rodriguez-Baez N1, Murray KF2, Kleiner DE3, Ling SC4, Rosenthal P5, Carlin K6, Cooper K6, Schwarz KB7, Schwarzenberg SJ8, Teckman JH9, Ghany MG10, Alawad A10. Abstract OBJECTIVES: Chronic hepatitis B virus infection is a major cause of morbidity and mortality. The aim of the study is to describe the hepatic histology in children chronically infected with hepatitis B virus living in the United States and Canada. METHODS: Published on: Apr-2020 Read more

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