Event Videos

https://www.ncbi.nlm.nih.gov/pubmed/29162346

Liver transplant

J Pediatr. 2017 Nov 18. pii: S0022-3476(17)31323-9. doi: 10.1016/j.jpeds.2017.09.069. [Epub ahead of print]

Annunziato RA, Bucuvalas JC, Yin W, Arnand R, Alonso EM, Mazariegos GV, Venick RS, Stuber ML, Shneider BL, Shemesh E.

Abstract

OBJECTIVE:
To further refine a measure of self-management, the Responsibility and Familiarity with Illness Survey (REFILS), and to determine if this score predicts medication adherence and, thus, fewer instances of allograft rejection among pediatric liver transplant recipients.

STUDY DESIGN:

Published on: 
Nov-2017

https://www.ncbi.nlm.nih.gov/pubmed/29168311

Primary sclerosing cholangitis

Hepatol Res. 2017 Nov 22. doi: 10.1111/hepr.13004. [Epub ahead of print]
Umetsu S, Inui A, Sogo T, Komatsu H, Fujisawa T.

Abstract

BACKGROUND:
Wisteria floribunda agglutinin positive Mac-2 binding protein (WFA+ -M2BP) is a novel serum marker of hepatic fibrosis in adults with chronic hepatitis C. However, it remains unclear whether serum WFA+ -M2BP levels are associated with the progression of liverhistology in primary sclerosing cholangitis (PSC) .

METHODS:

Published on: 
Nov-2017

https://www.ncbi.nlm.nih.gov/pubmed/29183422

S Afr Med J. 2017 Nov 6;107(10):12130.
Tyraskis A, Durkin N, Davenport M.

Abstract
Congenital vascular anomalies of the liver include a range of malformations of the portal venous, hepatic arterial and venous systems. Congenital portosystemic shunts and arteriovenous malformations make up the two most frequent such malformations. While infantile haemangiomas of the liver, endothelial tumours characterised by vascular proliferation should also be considered, as a proportion of them form prenatally. Evidence to support treatment strategies for these infants and children has been mainly based on small case series. In this review, we explore classification, clinical presentation, investigation and treatment strategies.

Published on: 
Nov-2017

https://www.ncbi.nlm.nih.gov/pubmed/29174177

Cholestasis

J Pediatr Surg. 2017 Nov 23. pii: S0022-3468(17)30711-X. doi: 10.1016/j.jpedsurg.2017.10.055. [Epub ahead of print]
Erginel B, Soysal FG, Durmaz O, Celik A, Salman T.

Abstract

BACKGROUND:
Partial internal biliary diversion (PIBD) is an alternative approach for the treatment of devastating pruritus in patients with progressive familial intrahepatic cholestasis (PFIC). In these patients quality of life can be improved and progression of liver disease can be delayed while waiting for liver transplantation. The aim of our study was to evaluate six patients with PFIC who have undergone PIBD in long-term follow-up.

METHODS:

Published on: 
Nov-2017

https://www.ncbi.nlm.nih.gov/pubmed/29183423
Biliary atresia

S Afr Med J. 2017 Nov 6;107(10):12131.

De Maayer T, Lala SG, Loveland J, Okudo G, Mohanlal R, Hajinicolaou C.

Abstract

BACKGROUND:
Without timely surgical intervention, most children with biliary atresia (BA) are not expected to live beyond 2 years of age. The initial intervention, the Kasai hepatoportoenterostomy (KPE), aims to achieve biliary drainage. Liver transplantation (LT) is performed if jaundice fails to clear or when biliary cirrhosis occurs. In under-resourced South African (SA) academic state hospitals, KPE procedures are the standard of care for the majority of children with BA, but LT is becoming more routinely available.

OBJECTIVES:

Published on: 
Nov-2017

https://www.ncbi.nlm.nih.gov/pubmed/29176474

Neonatal Jaundice

J Pediatr Gastroenterol Nutr. 2017 Nov 22. doi: 10.1097/MPG.0000000000001843. [Epub ahead of print]

Mitchell E, Ranganathan S, McKiernan P, Squires RH, Strauss K, Soltys K, Mazariegos G, Squires JE.

Abstract

BACKGROUND:
Crigler-Najjar syndrome type I (CNI) arises from biallelic variants of UGT1A1 that abrogate UGT1A1 activity resulting in unconjugated hyperbilirubinemia. Historically, liver parenchyma in CNI was considered structurally and histologically normal. Recent review of CNI liver explants revealed fibrosis. Our aim was to investigate the association between hepatic histology and disease phenotype in CNI.

METHODS:

Published on: 
Nov-2017

https://www.ncbi.nlm.nih.gov/pubmed/29187144 NAFLD

BMC Gastroenterol. 2017 Nov 29;17(1):135. doi: 10.1186/s12876-017-0677-7.

Rajindrajith S, Pathmeswaran A, Jayasinghe C, Kottahachchi D, Kasturiratne A, de Silva ST, Niriella MA, Dassanayake AS, de Silva AP, de Silva HJ.

Abstract

BACKGROUND:
Nonalcoholic fatty liver disease (NAFLD) is a common problem across the world. We aimed to determine the prevalence of NAFLD and its associations in Sri Lankan adolescents living in an urban Sri Lankan community.

METHOD:

Published on: 
Nov-2017

https://www.ncbi.nlm.nih.gov/pubmed/29176477 Portal Hypertension

J Pediatr Gastroenterol Nutr. 2017 Nov 22. doi: 10.1097/MPG.0000000000001841. [Epub ahead of print]

Adami MR, Kieling CO, Schwengber FP, Hirakata VN, Vieira SMG.

Abstract

OBJECTIVE:
Esophageal variceal bleeding is a severe complication of portal hypertension. The standard diagnostic screening test and therapeutic procedure for esophageal varices is endoscopy, which is invasive in pediatric patients. This study aimed to evaluate the role of noninvasive parameters as predictors of large varices in children with intrahepatic portal hypertension.

METHODS:

Published on: 
Nov-2017

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