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Atypical clinical presentation and successful treatment with oral cholic acid of a child with defective bile acid synthesis due to a novel mutation in the HSD3B7 gene

https://www.ncbi.nlm.nih.gov/pubmed/29081931 Cholestasis

Pediatr Rep. 2017 Oct 10;9(3):7266. doi: 10.4081/pr.2017.7266. eCollection 2017 Oct 6.

Atypical clinical presentation and successful treatment with oral cholic acid of a child with defective bile acid synthesis due to a novel mutation in the HSD3B7 gene. Bossi G, Giordano G, Rispoli GA, Maggiore G, Naturale M, Marchetti D, Iascone M.

Abstract

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Oct-2017
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Waist-to-height ratio is a useful index for nonalcoholic fatty liver disease in children and adolescents: a secondary data analysis

https://www.ncbi.nlm.nih.gov/pubmed/29084519 NAFLD

BMC Public Health. 2017 Oct 30;17(1):851. doi: 10.1186/s12889-017-4868-5.

Waist-to-height ratio is a useful index for nonalcoholic fatty liver disease in children and adolescents: a secondary data analysis. Lin MS, Lin TH, Guo SE, Tsai MH, Chiang MS, Huang TJ, Chen MY.

Abstract

BACKGROUND:

Nonalcoholic fatty liver disease (NAFLD) is a global problem and pediatric obesity has risen dramatically. Early NAFLD might progress to nonalcoholic steatohepatitis (NASH) or liver cirrhosis and significantly increase liver disease-related mortality. We looked for NAFLD predictors in children and adolescents.

METHODS:

Published on: 
Oct-2017
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Molecular signature of active fibrogenesis prevails in biliary atresia after successful portoenterostomy.

https://www.ncbi.nlm.nih.gov/pubmed/28655415 Biliary atresia

Kerola A, Lampela H, Lohi J, Heikkilä P, Mutanen A, Jalanko H, Pakarinen MP.

Surgery. 2017 Sep;162(3):548-556. doi: 10.1016/j.surg.2017.04.013. Epub 2017 Jun 24.

Abstract

BACKGROUND:

In biliary atresia mechanisms of progressive liver injury leading to need of liver transplantation after successful portoenterostomy remain unknown. A better understanding is a prerequisite for development of novel therapies to extend native liversurvival, and we aimed to unravel molecular characteristics of liver injury after successful portoenterostomy.

METHODS:

Published on: 
Sep-2017
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Expanding the Margins: High Volume Utilization of Marginal Liver Grafts Among >2000 Liver Transplants at a Single Institution.

https://www.ncbi.nlm.nih.gov/pubmed/28657945 Liver transplant

Halazun KJ1, Quillin RC, Rosenblatt R, Bongu A, Griesemer AD, Kato T, Smith C, Michelassi F, Guarrera JV, Samstein B, Brown RS Jr, Emond JC.

Ann Surg. 2017 Sep;266(3):441-449. doi: 10.1097/SLA.0000000000002383.

Abstract

OBJECTIVE:

Marginal livers (ML) have been used to expand the donor pool. National utilization of MLs is variable, and in some centers, they are never used. We examined the outcomes of MLs in the largest single center series of MLs used to date and compared outcomes to standard (SL) and living donor (LD) livers.

METHODS:

Published on: 
Sep-2017
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A 4 and a half years old boy with mesenchymal hamartomas in the left lateral lobe of the liver: A case report and literature review.

https://www.ncbi.nlm.nih.gov/pubmed/28767567

Liao W1, Zhang B, Zhang W, Chen L, Zhang W, Zhang B, Chen X.

Medicine (Baltimore). 2017 Aug;96(31):e7281. doi: 10.1097/MD.0000000000007281.

Abstract

RATIONALE:

Mesenchymal hamartomas of the liver is one type of rare liver tumor.

PATIENT CONCERNS:

Mesenchymal hamartomas of the liver (MHL) is rarely reported in the left lobe of the liver in children who are more than 2 years old. It is difficult to distinguish it from liver lesions such as hepatoblastoma in children, and hepatocellular carcinoma and focal nodular hyperplasia in adults. In addition, it is hard to correctly diagnose it without pathological examination.

DIAGNOSES:

Mesenchymal hamartomas of the liver.

INTERVENTIONS:

Published on: 
Sep-2017
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Biliary Complications after Hepatic Trauma in Children

https://www.ncbi.nlm.nih.gov/pubmed/29097861

J Emerg Trauma Shock. 2017 Oct-Dec;10(4):211-214. doi: 10.4103/JETS.JETS_136_16.

Biliary Complications after Hepatic Trauma in Children.
Guanà R, Giulia C, Brunati A, Garofalo S, Schleef J.

Abstract

AIM OF THE STUDY:

In pediatric patients with liver trauma and hemodynamic stability, conservative treatment is acknowledged as the gold standard.

PATIENTS AND METHODS:

We conducted a retrospective analysis of 116 consecutive pediatric patients (<14-year-old) observed at our institution for closed abdominal trauma from January 2010 to January 2016. Among these, 16 patients (13%) had hepatic trauma Grade II or more, according to Moore liver trauma injury score.

RESULTS:

Published on: 
Oct-2017
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