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Management of Hepatoblastoma: ICMR Consensus Document https://www.ncbi.nlm.nih.gov/pubmed/28353129 Agarwala S, Gupta A, Bansal D, Vora T, Prasad M, Arora B, Kapoor G, Chinnaswamy G, Radhakrishnan V, Laskar S, Kaur T, Dhaliwal RS, Rath GK, Bakhshi S. Indian J Pediatr. 2017 Mar 29. Abstract Published on: Mar-2017 Read more	Prediabetes in Pediatric Recipients of Liver Transplant: Mechanism and Risk Factors. https://www.ncbi.nlm.nih.gov/pubmed/28041666 Perito ER, Lustig RH, Rosenthal P. J Pediatr. 2017 Mar;182:223-231.e3 Abstract OBJECTIVE: To investigate the role of calcineurin inhibitor exposure and states of insulin resistance-obesity and adolescence-in prediabetes after pediatric liver transplant via oral glucose tolerance testing, which previously has not been done systematically in these at-risk youths. STUDY DESIGN: This was a cross-sectional study of 81 pediatric recipients of liver transplant. Prediabetes was defined as impaired glucose tolerance (IGT; glucose ≥140 mg/dL at 2 hours) or impaired fasting glucose (IFG, ≥100 mg/dL). Corrected insulin response (CIR) was calculated as measure of insulin secretion, corrected for glucose (CIR30, CIR60, CIR120). RESULTS: Published on: Mar-2017 Read more
Early and late factors impacting patient and graft outcome in pediatric liver transplantation: summary of an ESPGHAN Monothematic Conference. https://www.ncbi.nlm.nih.gov/pubmed/28319600 McLin VA, Allen U, Boyer O, Bucuvalas J, Colledan M, Cuturi MC, d'Antiga L, Debray D, Dezsofi A, Goyet JV, Dhawan A, Durmaz O, Falk C, Feng S, Fischler B, Franchi-Abella S, Frauca E, Ganschow R, Gottschalk S, Hadzic N, Hierro L, Horslen S, Hubscher S, Karam V, Kelly D, Maecker-Kolhoff B, Mazariegos G, McKiernan P, Melk A, Nobili V, Ozgenç F, Reding R, Sciveres M, Sharif K, Socha P, Toso C, Vajro P, Verma A, Wildhaber BE, Baumann U. J Pediatr Gastroenterol Nutr. 2017 Mar 17 Abstract Published on: Mar-2017 Read more	Lactate and Lactate: Pyruvate Ratio in the Diagnosis and Outcomes of Pediatric Acute Liver Failure https://www.ncbi.nlm.nih.gov/pubmed/28088395 Feldman AG, Sokol RJ, Hardison RM, Alonso EM, Squires RH, Narkewicz MR; Pediatric Acute Liver Failure Study Group. J Pediatr. 2017 Mar;182:217-222.e3 Abstract OBJECTIVES: To assess the accuracy of blood lactate and lactate: pyruvate molar ratio (L:P) as a screen for mitochondrial, respiratory chain, or fatty acid oxidation disorders in children with pediatric acute liver failure (PALF); to determine whether serum lactate ≥ 2.5 mmol/L or L:P ≥ 25 correlated with biochemical variables of clinical severity; and to determine whether lactate or L:P is associated with clinical outcome at 21 days. STUDY DESIGN: Published on: Mar-2017 Read more
Normograms for the Extrahepatic Bile Duct Diameter in Children. https://www.ncbi.nlm.nih.gov/pubmed/27513696 Feng A, O'hara SM, Gupta R, Fei L, Lin TK. J Pediatr Gastroenterol Nutr. 2017 Mar;64(3):e61-e64. Abstract OBJECTIVE: The normal diameter of the extrahepatic bile duct (EHD) in children has been poorly studied. Prior studies have enrolled small subject numbers, have studied only specific pediatric age groups, or have potential bias due to loosely defined exclusion criteria. We sought to establish parameters for the normal diameter of the EHD in children from birth to late adolescence, including premature infants. METHODS: Published on: Mar-2017 Read more	Outcomes in Pediatric Autoimmune Hepatitis and Significance of Azathioprine Metabolites. https://www.ncbi.nlm.nih.gov/pubmed/28272159 Sheiko MA, Sundaram SS, Capocelli KE, Pan Z, McCoy AM, Mack CL. J Pediatr Gastroenterol Nutr. 2017 Mar 7. Abstract OBJECTIVES: Autoimmune hepatitis (AIH) is a common pediatric liver disease and long-term remission is usually maintained with azathioprine (AZA). There is no consensus on the target range for AZA active metabolite 6-thioguanine (6-TGN) levels in pediatric AIH. The aim of this study was to characterize the outcomes of pediatric patients with AIH and determine correlations between AZA dosing or 6-TGN metabolite levels and biochemical remission. METHODS: A retrospective chart review was performed and data on presentation, laboratories including AZA metabolite levels, medication use and outcomes was collected. Published on: Mar-2017 Read more
King's Variceal Prediction Score: A Novel Noninvasive Marker of Portal Hypertension in Pediatric Chronic Liver Disease. https://www.ncbi.nlm.nih.gov/pubmed/27749613 Witters P, Hughes D, Karthikeyan P, Ramakrishna S, Davenport M, Dhawan A, Grammatikopoulos T. J Pediatr Gastroenterol Nutr. 2017 Apr;64(4):518-523. Abstract BACKGROUND AND AIMS: Variceal haemorrhage can be a life-threatening complication of chronic liver disease in children. There is limited evidence about the optimal prophylactic management and selection criteria of children who will benefit from upper gastrointestinal endoscopy. METHODS: Published on: Mar-2017 Read more	Low Hepatic Tissue Copper in Pediatric Non-Alcoholic Fatty Liver Disease https://www.ncbi.nlm.nih.gov/pubmed/28319602 Mendoza M, Caltharp S, Song M, Collin L, Konomi JV, McClain CJ, Vos MB. J Pediatr Gastroenterol Nutr. 2017 Mar 17. Abstract OBJECTIVE: Animal models and studies in adults have demonstrated that copper restriction increases severity of liver injury in non-alcoholic fatty liver disease (NAFLD). This has not been studied in children. We aimed to determine if lower tissue copper is associated with increased NAFLD severity in children. METHODS: Published on: Mar-2017 Read more
Liver Transplantation for Children With Primary Sclerosing Cholangitis and Autoimmune Hepatitis: UNOS Database Analysis. https://www.ncbi.nlm.nih.gov/pubmed/27755342 Jossen J, Annunziato R, Kim HS, Chu J, Arnon R. J Pediatr Gastroenterol Nutr. 2017 Apr;64(4):e83-e87 Abstract OBJECTIVES: Autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC) are progressive immune-mediated inflammatory diseases that may require liver transplant (LT). Outcomes in children undergoing LT for these diseases are poorly studied in the pediatric end-stage liver disease era. We aimed to characterize the outcome of LT in children with AIH and PSC. METHODS: Children 18 years or younger with PSC or AIH who had a first, isolated LT from 2002 to 2012 were identified from the United Network for Organ Sharing database. Graft and patient outcomes were studied. RESULTS: Published on: Mar-2017 Read more	Management of Pediatric Non-alcoholic Fatty Liver Disease By Academic Hepatologists in Canada: A Nationwide Survey. https://www.ncbi.nlm.nih.gov/pubmed/28333768 Mouzaki M, Ling SC, Schreiber RA, Kamath BM. J Pediatr Gastroenterol Nutr. 2017 Mar 22. Abstract BACKGROUND: The literature on the optimal clinical management of pediatric patients with non-alcoholic fatty liver disease (NAFLD) is limited. The objective of this study was to identify discrepancies in the care provided to patients with NAFLD by hepatologists practicing in academic centers across Canada. METHODS: A nationwide survey was distributed electronically to all pediatric hepatologists practicing in university-affiliated hospitals using the infrastructure of the Canadian Pediatric Hepatology Research Group. The responses were anonymous. RESULTS: Published on: Mar-2017 Read more

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