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Clinical Characteristics and Complications of Pediatric Liver Biopsy: A Single Centre Experience

https://www.ncbi.nlm.nih.gov/pubmed/28809725

Ann Hepatol. 2017 Aug 8;16(5):797-801. doi: 10.5604/01.3001.0010.2809.
Almeida P1, Schreiber RA1, Liang J1, Mujawar Q2, Guttman OR1.

Abstract

INTRODUCTION:
Percutaneous liver biopsy (LB) is the gold standard method for evaluation and management of patients with liver disease. The purpose of this study was to characterize pediatric patients undergoing LB at British Columbia Children & apos;s Hospital, and to determine the rate and timing of complications following the procedure.

MATERIAL AND METHODS:
The medical records of all pediatric patients who underwent LB during a six-year retrospective study were reviewed to collect demographic and procedure-related data.

RESULTS:

Published on: 
Jul-2017
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Outcomes in Pediatric Autoimmune Hepatitis and Significance of Azathioprine Metabolites

https://www.ncbi.nlm.nih.gov/pubmed/28272159

Sheiko, Melissa A.*,†; Sundaram, Shikha S.*,†; Capocelli, Kelley E.‡,§; Pan, Zhaoxing||; McCoy, Annette M.*,†; Mack, Cara L.*,†
Journal of Pediatric Gastroenterology & Nutrition: July 2017 - Volume 65 - Issue 1 - p 80–85

Objectives:

Autoimmune hepatitis (AIH) is a common pediatric liver disease and long-term remission is usually maintained with azathioprine (AZA). There is no consensus on the target range for AZA active metabolite 6-thioguanine (6-TGN) levels in pediatric AIH. The aim of the present study was to characterize the outcomes of pediatric patients with AIH and determine correlations between AZA dosing or 6-TGN metabolite levels and biochemical remission.

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Jun-2017
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Early Onset of Wilson Disease - Diagnostic Challenges

https://www.ncbi.nlm.nih.gov/pubmed/28753182
J Pediatr Gastroenterol Nutr. 2017 Jul 27. doi: 10.1097/MPG.0000000000001700.

Wiernicka A1, Dądalski M, Jańczyk W, Kamińska D, Naorniakowska M, Hüsing-Kabar A, Schmidt H, Socha P.

Abstract

OBJECTIVES:
To analyze the clinical presentations, diagnosis and treatment of patients aged ≤ 5 years with early onset Wilson disease (WD).

METHODS:
Data from 143 pediatric patients with WD treated at our center between January 1996 and November 2015 were retrospectively analyzed.

RESULTS:

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Jul-2017
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Low Hepatic Tissue Copper in Pediatric Nonalcoholic Fatty Liver Disease

https://www.ncbi.nlm.nih.gov/pubmed/28644356

Mendoza, Michael*; Caltharp, Shelley†,‡; Song, Ming§; Collin, Lindsay*; Konomi, Juna V.*; McClain, Craig J.§; Vos, Miriam B.*,‡
Journal of Pediatric Gastroenterology & Nutrition: July 2017 - Volume 65 - Issue 1 - p 89–92

ABSTRACT

Objective:

Animal models and studies in adults have demonstrated that copper restriction increases severity of liver injury in nonalcoholic fatty liver disease (NAFLD). This has not been studied in children. We aimed to determine if lower tissue copper is associated with increased NAFLD severity in children.

Methods:

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Jun-2017
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Bilateral diaphragmatic paresis following pediatric liver transplantation.

https://www.ncbi.nlm.nih.gov/pubmed/28781878

Olmscheid J1,2, Molero H3, Gershan W3, Demirel N3.

Abstract

BACKGROUND:
Although diaphragm paresis or paralysis is fairly common following cardiac procedures; it is a less common complication following liver transplantation. Unilateral diaphragm paresis, usually right sided, has been described following liver transplantation in adults and has been rarely described in children.

PURPOSE:
Diaphragmatic injury following LT is often unrecognized and is typically unilateral, involving the right hemidiaphragm. Bilateral diaphragm dysfunction following liver transplantation in children is a rare complication.

METHODS:

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Jul-2017
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Randomised clinical trial: sofosbuvir and ledipasvir in patients with transfusion-dependent thalassaemia and HCV genotype 1 or 4 infection

https://www.ncbi.nlm.nih.gov/pubmed/28660640

Mangia A1, Sarli R2, Gamberini R3, Piga A4, Cenderello G5, Piazzolla V1, Santoro R1, Caruso V6, Quarta A7, Ganga R8, Copetti M9, Forni G10.

ABSTRACT

BACKGROUND:
Patients with thalassaemia major depend on blood transfusions. In Italy, up to 80% of thalassaemia patients bear HCV antibodies due to HCV contaminated transfusions before 1990. Thalassaemia patients with HCV infection have high risk of developing HCC. Treatment based on Pegylated-IFN (Peg-IFN) and Ribavirin (RBV) was limited by relevant side effects.

AIM:
To evaluate the impact of Sofosbuvir/Ledipasvir (SOF/LDV) fixed dose combination for 12 weeks without RBV, in patients with thalassaemia major and HCV Genotype 1 or 4 (GT1/4).

METHODS:

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Jun-2017
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Successful management of acute liver failure in Italian children: A 16-year experience at a referral centre for paediatric liver transplantation

https://www.ncbi.nlm.nih.gov/pubmed/28663066

Di Giorgio A1, Sonzogni A2, Piccichè A3, Alessio G4, Bonanomi E5, Colledan M6, D'Antiga L7.

ABSTRACT

BACKGROUND:
Identifying the causes of acute liver failure (ALF) and predictors of death or liver transplantation (LTX) is crucial to decide its management. We aimed to describe features and outcome of ALF in Italian children.

METHODS:
Retrospective review of cases presenting between 1996-2012. ALF was defined by high transaminases, INR ≥2.0 regardless of hepatic encephalopathy (HE), no evidence of underlying chronic liver disease.

RESULTS:

Published on: 
Jun-2017
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