Event Videos

Lactate and Lactate: Pyruvate Ratio in the Diagnosis and Outcomes of Pediatric Acute Liver Failure

https://www.ncbi.nlm.nih.gov/pubmed/28088395

Feldman AG, Sokol RJ, Hardison RM, Alonso EM, Squires RH, Narkewicz MR; Pediatric Acute Liver Failure Study Group. J Pediatr. 2017 Mar;182:217-222.e3

Abstract
OBJECTIVES:
To assess the accuracy of blood lactate and lactate: pyruvate molar ratio (L:P) as a screen for mitochondrial, respiratory chain, or fatty acid oxidation disorders in children with pediatric acute liver failure (PALF); to determine whether serum lactate ≥ 2.5 mmol/L or L:P  ≥ 25 correlated with biochemical variables of clinical severity; and to determine whether lactate or L:P is associated with clinical outcome at 21 days.

STUDY DESIGN:

Published on: 
Mar-2017
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Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

https://www.ncbi.nlm.nih.gov/pubmed/28366357

Newton KP, Feldman HS, Chambers CD, Wilson L, Behling C, Clark JM, Molleston JP, Chalasani N, Sanyal AJ, Fishbein MH, Lavine JE, Schwimmer JB; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN).J Pediatr. 2017 Mar 30. pii: S0022-3476(17)30356-6. doi: 10.1016/j.jpeds.2017.03.007.

Abstract

OBJECTIVES:
To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD.

STUDY DESIGN:

Published on: 
Mar-2017
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Outcomes in Pediatric Autoimmune Hepatitis and Significance of Azathioprine Metabolites.

https://www.ncbi.nlm.nih.gov/pubmed/28272159

Sheiko MA, Sundaram SS, Capocelli KE, Pan Z, McCoy AM, Mack CL. J Pediatr Gastroenterol Nutr. 2017 Mar 7.

Abstract

OBJECTIVES:
Autoimmune hepatitis (AIH) is a common pediatric liver disease and long-term remission is usually maintained with azathioprine (AZA). There is no consensus on the target range for AZA active metabolite 6-thioguanine (6-TGN) levels in pediatric AIH. The aim of this study was to characterize the outcomes of pediatric patients with AIH and determine correlations between AZA dosing or 6-TGN metabolite levels and biochemical remission.

METHODS:
A retrospective chart review was performed and data on presentation, laboratories including AZA metabolite levels, medication use and outcomes was collected.

Published on: 
Mar-2017
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Low Hepatic Tissue Copper in Pediatric Non-Alcoholic Fatty Liver Disease

https://www.ncbi.nlm.nih.gov/pubmed/28319602

Mendoza M, Caltharp S, Song M, Collin L, Konomi JV, McClain CJ, Vos MB. J Pediatr Gastroenterol Nutr. 2017 Mar 17.

Abstract

OBJECTIVE:
Animal models and studies in adults have demonstrated that copper restriction increases severity of liver injury in non-alcoholic fatty liver disease (NAFLD). This has not been studied in children. We aimed to determine if lower tissue copper is associated with increased NAFLD severity in children.

METHODS:

Published on: 
Mar-2017
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Management of Pediatric Non-alcoholic Fatty Liver Disease By Academic Hepatologists in Canada: A Nationwide Survey.

https://www.ncbi.nlm.nih.gov/pubmed/28333768

Mouzaki M, Ling SC, Schreiber RA, Kamath BM. J Pediatr Gastroenterol Nutr. 2017 Mar 22.

Abstract

BACKGROUND:
The literature on the optimal clinical management of pediatric patients with non-alcoholic fatty liver disease (NAFLD) is limited. The objective of this study was to identify discrepancies in the care provided to patients with NAFLD by hepatologists practicing in academic centers across Canada.

METHODS:
A nationwide survey was distributed electronically to all pediatric hepatologists practicing in university-affiliated hospitals using the infrastructure of the Canadian Pediatric Hepatology Research Group. The responses were anonymous.

RESULTS:

Published on: 
Mar-2017
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Portal hypertension in children: High-risk varices, primary prophylaxis and consequences of bleeding

https://www.ncbi.nlm.nih.gov/pubmed/27663417

Duché M, Ducot B, Ackermann O, Guérin F, Jacquemin E, Bernard O. J Hepatol. 2017 Feb;66(2):320-327.

Abstract

BACKGROUND & AIMS:
Primary prophylaxis of bleeding is debated for children with portal hypertension because of the limited number of studies on its safety and efficacy, the lack of a known endoscopic pattern carrying a high-risk of bleeding for all causes, and the assumption that the mortality of a first bleed is low. We report our experience with these issues.

METHODS:

Published on: 
Feb-2017
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Childhood Adiposity and Nonalcoholic Fatty Liver Disease in Adulthood

https://www.ncbi.nlm.nih.gov/pubmed/28356335

Yan Y, Hou D, Zhao X, Liu J, Cheng H, Wang Y, Mi J. Pediatrics. 2017 Mar 29. pii: e20162738. doi: 10.1542/peds.2016-2738. [

Abstract

OBJECTIVE:
To investigate the association of childhood adiposity and change in adiposity status from childhood to adulthood with nonalcoholic fatty liver disease (NAFLD) and abnormal liver enzyme levels in adulthood.

METHODS:

Published on: 
Mar-2017
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Respiratory Morbidity Following Pediatric Orthotopic Liver Transplantation

https://www.ncbi.nlm.nih.gov/pubmed/28159955

Alam S, Sapare A, Rao S, Aggarwal R, D'cruz AL. Indian Pediatr. 2017 Feb 2.

Abstract
We evaluated the pulmonary complications following orthotopic liver transplantation in children (age <18 y). Twenty-two patients (49%) developed respiratory complications. Pediatric end-stage liver disease(PELD) score >25 and positive fluid balance were independent risk factors. Patients with respiratory complication had significantly higher mortality and intensive care unit stay.

Published on: 
Feb-2017
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