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Non-cirrhotic Portal Fibrosis in Pediatric Population https://www.ncbi.nlm.nih.gov/pubmed/27906797 Sood V, Lal BB, Khanna R, Rawat D, Sharma CB, Alam S. J Pediatr Gastroenterol Nutr. 2016 Nov 30. Abstract BACKGROUND: Non-cirrhotic portal fibrosis (NCPF) has been classically described as a disease of young to middle age with limited literature regarding its occurrence, onset or clinical presentation in children. We hereby present a series of 19 patients diagnosed and managed as NCPF in pediatric age group. METHODS: A retrospective review of all the patients presenting to the pediatric hepatology department (age < 18 years) and diagnosed as NCPF was done and data was evaluated. RESULTS: Published on: Nov-2016 Read more	Liver Transplantation for Children with Primary Sclerosing Cholangitis and Autoimmune Hepatitis: UNOS Database Analysis. https://www.ncbi.nlm.nih.gov/pubmed/27755342 Jossen J, Annunziato R, Kim HS, Chu J, Arnon R. J Pediatr Gastroenterol Nutr. 2016 Oct 13. Abstract OBJECTIVES: Autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC) are progressive immune-mediated inflammatory diseases that may require liver transplant (LT). Outcomes in children undergoing LT for these diseases are poorly studied in the Pediatric End Stage Liver Disease (PELD) era. We aimed to characterize the outcome of LT in children with AIH and PSC. METHODS: Children ≤18 years with PSC or AIH who had a first, isolated LT from 2002-2012 were identified from the UNOS database. Graft and patient outcomes were studied. RESULTS: Published on: Oct-2016 Read more
Non-cirrhotic Portal Fibrosis in Pediatric Population https://www.ncbi.nlm.nih.gov/pubmed/27906797 Sood V, Lal BB, Khanna R, Rawat D, Sharma CB, Alam S. J Pediatr Gastroenterol Nutr. 2016 Nov 30. Abstract BACKGROUND: Non-cirrhotic portal fibrosis (NCPF) has been classically described as a disease of young to middle age with limited literature regarding its occurrence, onset or clinical presentation in children. We hereby present a series of 19 patients diagnosed and managed as NCPF in pediatric age group. METHODS: A retrospective review of all the patients presenting to the pediatric hepatology department (age < 18 years) and diagnosed as NCPF was done and data was evaluated. RESULTS: Published on: Nov-2016 Read more	Correlation of Transient Elastography With Severity of Cystic Fibrosis Related Liver Disease https://www.ncbi.nlm.nih.gov/pubmed/27782957 Aqul A, Jonas MM, Harney S, Raza R, Sawicki GS, Mitchell PD, Fawaz R. J Pediatr Gastroenterol Nutr. 2016 Oct 25. Abstract OBJECTIVE: To evaluate whether liver stiffness measurement (LSM), determined by transient elastography (TE), correlates with presence and severity of liver disease (LD) in children and young adults with cystic fibrosis (CF). METHODS: Subjects underwent LSM at routine CF visits. Presence and severity of CFLD was determined by clinical parameters. Subjects were classified as no CFLD, CFLD without portal hypertension (PHTN), and CFLD with PHTN. LSM was compared to AST/platelet ratio index (APRI) as a correlate to severity of CFLD. RESULTS: Published on: Oct-2016 Read more
NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children https://www.ncbi.nlm.nih.gov/pubmed/27906803 Vos MB, Abrams SH, Barlow SE, Caprio S, Daniels SR, Kohli R, Mouzaki M, Sathya P, Schwimmer JB, Sundaram SS, Xanthakos SA. J Pediatr Gastroenterol Nutr. 2016 Nov 30. Abstract Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease that occurs in the setting of insulin resistance and increased adiposity. It has rapidly evolved into the most common liver disease seen in the pediatric population and is a management challenge for general pediatric practitioners, subspecialists and for health systems. In this guideline, the expert committee on NAFLD (ECON) reviewed and summarized the available literature, formulating recommendations to guide screening and clinical care of children with NAFLD. Published on: Nov-2016	Intensive Care Management of Pediatric Acute Liver Failure https://www.ncbi.nlm.nih.gov/pubmed/27741059 Acute liver failure Lutfi R, Abulebda K, Nitu ME, Molleston JP, Bozic MA, Subbarao G. J Pediatr Gastroenterol Nutr. 2016 Oct 12 Abstract Published on: Oct-2016 Read more
Long-Term Ursodeoxycholic Acid Therapy Does Not Alter Lithocholic Acid Levels in Patients with Cystic Fibrosis with Associated Liver Disease https://www.ncbi.nlm.nih.gov/pubmed/27297203 . Colombo C, Crosignani A, Alicandro G, Zhang W, Biffi A, Motta V, Corti F, Setchell KD. J Pediatr. 2016 Oct;177:59-65.e1. doi: 10.1016/j.jpeds.2016.05.008. Abstract OBJECTIVE: To evaluate the fasting and postprandial serum bile acid composition in patients with cystic fibrosis-associated liver disease (CFLD) after chronic administration of ursodeoxycholic acid (UDCA) (20 mg/kg/day). The aim was to specifically focus on the extent of biotransformation of UDCA to its hepatotoxic metabolite, lithocholic acid, because of recent concerns regarding the safety of long-term, high-dose UDCA treatment for CFLD. STUDY DESIGN: Published on: Oct-2016 Read more	Outcomes of Children With and Without Hepatic Encephalopathy From the Pediatric Acute Liver Failure Study Group https://www.ncbi.nlm.nih.gov/pubmed/27367788 Ng VL, Li R, Loomes KM, Leonis MA, Rudnick DA, Belle SH, Squires RH; Pediatric Acute Liver Failure Study Group (PALFSG). J Pediatr Gastroenterol Nutr. 2016 Sep;63(3):357-64. doi: 10.1097/MPG.0000000000001178 Abstract OBJECTIVES: Hepatic encephalopathy (HE) is challenging to identify in children with acute liver failure and was not a requirement for enrollment into the Pediatric Acute Liver Failure Study Group (PALFSG). The outcomes of PALFSG participants presenting with and without HE are presented. METHODS: Published on: Sep-2016 Read more
King's variceal Prediction Score: A Novel Non-Invasive Marker of Portal Hypertension in Paediatric Chronic Liver Disease https://www.ncbi.nlm.nih.gov/pubmed/27749613 Witters P, Hughes D, Karthikeyan P, Ramakrishna S, Davenport M, Dhawan A, Grammatikopoulos T. J Pediatr Gastroenterol Nutr. 2016 Oct 4. Abstract BACKGROUND AND AIMS: Variceal haemorrhage can be a life-threatening complication of chronic liver disease in children. There is limited evidence about the optimal prophylactic management and selection criteria of children who will benefit from upper gastrointestinal endoscopy. METHODS: Published on: Oct-2016 Read more	Long-term Effects of Hepatitis B Immunization of Infants in Preventing Liver Cancer https://www.ncbi.nlm.nih.gov/pubmed/27269245 Chang MH, You SL, Chen CJ, Liu CJ, Lai MW, Wu TC, Wu SF, Lee CM, Yang SS, Chu HC, Wang TE, Chen BW, Chuang WL, Soon MS, Lin CY, Chiou ST, Kuo HS, Chen DS; Taiwan Hepatoma Study Group. Gastroenterology. 2016 Sep;151(3):472-480.e1. doi: 10.1053/j.gastro.2016.05.048. Epub 2016 Jun 4. Abstract BACKGROUND & AIMS: The incidence of hepatocellular carcinoma (HCC) increases with age, but protective antibody responses decrease with time after infants are immunized against hepatitis B virus (HBV). We investigated whether immunization of infants against HBV prevents their developing HCC as adults. We also searched for strategies to maximize the cancer-preventive effects. METHODS: Published on: Sep-2016 Read more

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