Event Videos

Management of Pediatric Non-alcoholic Fatty Liver Disease By Academic Hepatologists in Canada: A Nationwide Survey.

https://www.ncbi.nlm.nih.gov/pubmed/28333768

Mouzaki M, Ling SC, Schreiber RA, Kamath BM. J Pediatr Gastroenterol Nutr. 2017 Mar 22.

Abstract

BACKGROUND:
The literature on the optimal clinical management of pediatric patients with non-alcoholic fatty liver disease (NAFLD) is limited. The objective of this study was to identify discrepancies in the care provided to patients with NAFLD by hepatologists practicing in academic centers across Canada.

METHODS:
A nationwide survey was distributed electronically to all pediatric hepatologists practicing in university-affiliated hospitals using the infrastructure of the Canadian Pediatric Hepatology Research Group. The responses were anonymous.

RESULTS:

Published on: 
Mar-2017
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Portal hypertension in children: High-risk varices, primary prophylaxis and consequences of bleeding

https://www.ncbi.nlm.nih.gov/pubmed/27663417

Duché M, Ducot B, Ackermann O, Guérin F, Jacquemin E, Bernard O. J Hepatol. 2017 Feb;66(2):320-327.

Abstract

BACKGROUND & AIMS:
Primary prophylaxis of bleeding is debated for children with portal hypertension because of the limited number of studies on its safety and efficacy, the lack of a known endoscopic pattern carrying a high-risk of bleeding for all causes, and the assumption that the mortality of a first bleed is low. We report our experience with these issues.

METHODS:

Published on: 
Feb-2017
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Childhood Adiposity and Nonalcoholic Fatty Liver Disease in Adulthood

https://www.ncbi.nlm.nih.gov/pubmed/28356335

Yan Y, Hou D, Zhao X, Liu J, Cheng H, Wang Y, Mi J. Pediatrics. 2017 Mar 29. pii: e20162738. doi: 10.1542/peds.2016-2738. [

Abstract

OBJECTIVE:
To investigate the association of childhood adiposity and change in adiposity status from childhood to adulthood with nonalcoholic fatty liver disease (NAFLD) and abnormal liver enzyme levels in adulthood.

METHODS:

Published on: 
Mar-2017
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Respiratory Morbidity Following Pediatric Orthotopic Liver Transplantation

https://www.ncbi.nlm.nih.gov/pubmed/28159955

Alam S, Sapare A, Rao S, Aggarwal R, D'cruz AL. Indian Pediatr. 2017 Feb 2.

Abstract
We evaluated the pulmonary complications following orthotopic liver transplantation in children (age <18 y). Twenty-two patients (49%) developed respiratory complications. Pediatric end-stage liver disease(PELD) score >25 and positive fluid balance were independent risk factors. Patients with respiratory complication had significantly higher mortality and intensive care unit stay.

Published on: 
Feb-2017

Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

https://www.ncbi.nlm.nih.gov/pubmed/28366357

Newton KP, Feldman HS, Chambers CD, Wilson L, Behling C, Clark JM, Molleston JP, Chalasani N, Sanyal AJ, Fishbein MH, Lavine JE, Schwimmer JB; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN).J Pediatr. 2017 Mar 30. pii: S0022-3476(17)30356-6. doi: 10.1016/j.jpeds.2017.03.007.

Abstract

OBJECTIVES:
To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD.

STUDY DESIGN:

Published on: 
Mar-2017
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Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents

https://www.ncbi.nlm.nih.gov/pubmed/28214020

Mosca A, Nobili V, De Vito R, Crudele A, Scorletti E, Villani A, Alisi A, Byrne CD.
J Hepatol. 2017 Feb 6. pii: S0168-8278(17)30002-8

Abstract

BACKGROUND & AIMS:
Recent research has suggested that dietary fructose intake may increase serum uric acid (UA) concentrations. Both UA concentration and fructose consumption maybe also increase in NAFLD. It is not known whether dietary fructose consumption and UA concentration are independently associated with non-alcoholic steatohepatitis (NASH). Our aim was to investigate the factors associated with NASH in children and adolescents with proven NAFLD, and to test whether UA concentrations and fructose consumption are independently associated with NASH.

METHODS:

Published on: 
Feb-2017
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