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The dendritic cell-Th17-macrophage axis controls cholangiocyte injury and disease progression in murine and human biliary atresia https://www.ncbi.nlm.nih.gov/pubmed/27641439 Lages CS, Simmons J, Maddox A, Jones K, Karns R, Sheridan R, Shanmukhappa SK, Mohanty S, Kofron M, Russo P, Wang YH, Chougnet C, Miethke AG. Hepatology. 2016 Sep 19. doi: 10.1002/hep.28851. Abstract Published on: Sep-2016 Read more	Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease https://www.ncbi.nlm.nih.gov/pubmed/27501738 Sundaram SS, Halbower A, Pan Z, Robbins K, Capocelli KE, Klawitter J, Shearn CT, Sokol RJ. J Hepatol. 2016 Sep;65(3):560-9. doi: 10.1016/j.jhep.2016.04.010. Epub 2016 Aug 5. Abstract BACKGROUND & AIMS: Oxidative stress is proposed as a central mediator in NAFLD pathogenesis, but the specific trigger for reactive oxygen species generation has not been clearly delineated. In addition, emerging evidence shows that obesity related obstructive sleep apnea (OSA) and nocturnal hypoxia are associated with NAFLD progression in adults. The aim of this study was to determine if OSA/nocturnal hypoxia-induced oxidative stress promotes the progression of pediatric NAFLD. METHODS: Published on: Sep-2016 Read more
Complications of Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients; A Systematic Literature Review and Meta-Analysis https://www.ncbi.nlm.nih.gov/pubmed/27663215 Usatin D, Fernandes M, Allen IE, Perito ER, Ostroff J, Heyman MB. J Pediatr. 2016 Sep 20. pii: S0022-3476(16)30733-8. doi: 10.1016/j.jpeds.2016.08.046. Abstract OBJECTIVES: To systematically review risks and summarize reported complication rates associated with the performance of endoscopic retrograde cholangiopancreatography (ERCP) in children during the past 2 decades. STUDY DESIGN: Published on: Sep-2016 Read more	The Natural History of Primary Sclerosing Cholangitis in Children: A Large Single Center Longitudinal Cohort Study http://www.ncbi.nlm.nih.gov/pubmed/27504812 Valentino PL, Wiggins S, Harney S, Raza R, Lee CK, Jonas MM. J Pediatr Gastroenterol Nutr. 2016 Aug 6 Abstract OBJECTIVES: Data regarding pediatric PSC natural history are limited. We describe a large pediatric PSC cohort with longitudinal follow-up. METHODS: Records review of pediatric PSC patients diagnosed between 1984 and 2014. RESULTS: Published on: Aug-2016 Read more
Associations among the Degree of Nonalcoholic Fatty Liver Disease https://www.ncbi.nlm.nih.gov/pubmed/27738602 Metabolic Syndrome, Degree of Obesity in Children, and Parental Obesity. Oh MS, Kim S, Jang JH, Park JY, Kang HS, Lee MS, Kang KS. Pediatr Gastroenterol Hepatol Nutr. 2016 Sep;19(3):199-206. Abstract PURPOSE: To analyze the associations among the degrees of nonalcoholic fatty liver disease (NAFLD) by ultrasonography and metabolic syndrome, degrees of obesity in children, and degrees of parental obesity. METHODS: Published on: Sep-2016 Read more	Sertraline as an Additional Treatment for Cholestatic Pruritus in Childrens http://www.ncbi.nlm.nih.gov/pubmed/27557426 Thébaut A, Habes D, Gottrand F, Rivet C, Cohen J, Debray D, Jacquemin E, Gonzales E. J Pediatr Gastroenterol Nutr. 2016 Aug 24. Abstract BACKGROUNDS/AIM: Published on: Aug-2016 Read more
Congenital Vascular Malformations of the Liver: an Association With Trisomy 21. https://www.ncbi.nlm.nih.gov/pubmed/27602703 Burdall OC, Grammatikopoulos T, Sellars M, Hadzic N, Davenport M. J Pediatr Gastroenterol Nutr. 2016 Sep 6. Abstract Published on: Sep-2016 Read more	Hepatocellular Carcinoma Risk in Alaska Native Children and Young Adults with Hepatitis B Virus: Retrospective Cohort Analysis http://www.ncbi.nlm.nih.gov/pubmed/27590612 Gounder PP, Bulkow LR, Snowball M, Negus S, Spradling PR, McMahon BJ. J Pediatr. 2016 Aug 30. pii: S0022-3476(16)30683-7. Abstract OBJECTIVES: To evaluate the hepatocellular carcinoma (HCC) risk in Alaska Native children and young adults with hepatitis B virus (HBV). STUDY DESIGN: Published on: Aug-2016 Read more
Family Impact and Infant Emotional Outcomes Following Diagnosis of Serious Liver Disease or Transplantation in Infancy Bowden MR, Ee LC, Krishnan U, O'Loughlin EV, Hardikar W, Carmody D, Hainsworth C, Jermyn V, Lee MM, Sawyer J, Stormon M, Holmes K, Lemberg DA, Day AS, Paul C, Hazell P. J Pediatr Gastroenterol Nutr. 2016 Sep 24. Abstract OBJECTIVES: Research is lacking into the emotional effects on families of serious chronic illness in infants. We examined the impact of the diagnosis of serious liver disease in infants upon parent psychological symptoms and family functioning. We hypothesized that parent psychological symptoms, family functioning and father engagement will predict infant emotional outcomes. METHODS: Published on: Sep-2016 Read more	Prevalence and Significance of Autoantibodies in Children with Acute Liver Failure http://www.ncbi.nlm.nih.gov/pubmed/27496798 Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH; Pediatric Acute Liver Failure Study Group. J Pediatr Gastroenterol Nutr. 2016 Aug 4. Abstract OBJECTIVES: The purpose of this study is to estimate autoantibody (autoAB) frequency, clinical characteristics and 21 day outcome of participants in the Pediatric Acute Liver Failure Study Group (PALFSG) by ANA, SMA and LKM antibody status. METHODS: AutoAB were determined at local and/or central laboratories. Subjects were assigned to autoimmune hepatitis (AIH), indeterminate and other diagnoses groups. RESULTS: Published on: Aug-2016 Read more

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