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The Natural History of Primary Sclerosing Cholangitis in Children: A Large Single Center Longitudinal Cohort Study http://www.ncbi.nlm.nih.gov/pubmed/27504812 Valentino PL, Wiggins S, Harney S, Raza R, Lee CK, Jonas MM. J Pediatr Gastroenterol Nutr. 2016 Aug 6 Abstract OBJECTIVES: Data regarding pediatric PSC natural history are limited. We describe a large pediatric PSC cohort with longitudinal follow-up. METHODS: Records review of pediatric PSC patients diagnosed between 1984 and 2014. RESULTS: Published on: Aug-2016 Read more	Metabolic Liver Diseases Presenting as Acute Liver Failure in Children http://www.ncbi.nlm.nih.gov/pubmed/27395834 Alam S, Lal B. Indian Pediatr. 2016 Aug 8;53(8):695-701. Epub 2016 Jun 1. Abstract CONTEXT: Suspecting metabolic liver disease in an infant or young child with acute liver failure, and a protocol-based workup for diagnosis is the need of the hour. EVIDENCE ACQUISITION: Data over the last 15 years was searched through Pubmed using the keywords Metabolic liver disease and Acute liver failure with emphasis on Indian perspective. Those published in English language where full text was retrievable were included for this review. RESULTS: Published on: Aug-2016 Read more
Sertraline as an Additional Treatment for Cholestatic Pruritus in Childrens http://www.ncbi.nlm.nih.gov/pubmed/27557426 Thébaut A, Habes D, Gottrand F, Rivet C, Cohen J, Debray D, Jacquemin E, Gonzales E. J Pediatr Gastroenterol Nutr. 2016 Aug 24. Abstract BACKGROUNDS/AIM: Published on: Aug-2016 Read more	In Children with Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but does not Reduce Disease Activity Scores http://www.ncbi.nlm.nih.gov/pubmed/27569726 Schwimmer JB, Lavine JE, Wilson LA, Neuschwander-Tetri BA, Xanthakos SA, Kohli R, Barlow SE, Vos MB, Karpen SJ, Molleston JP, Whitington PF, Rosenthal P, Jain AK, Murray KF, Brunt EM, Kleiner DE, Van Natta ML, Clark JM, Tonascia J, Doo E; NASH CRN. Gastroenterology. 2016 Aug 25. Abstract BACKGROUND & AIMS: No treatment for nonalcoholic fatty liver disease (NAFLD) has been approved by regulatory agencies. We performed a randomized controlled trial to determine whether 52 weeks of cysteamine bitartrate delayed release (CBDR) reduces the severity of liver disease in children with NAFLD. METHODS: Published on: Aug-2016 Read more
Hepatocellular Carcinoma Risk in Alaska Native Children and Young Adults with Hepatitis B Virus: Retrospective Cohort Analysis http://www.ncbi.nlm.nih.gov/pubmed/27590612 Gounder PP, Bulkow LR, Snowball M, Negus S, Spradling PR, McMahon BJ. J Pediatr. 2016 Aug 30. pii: S0022-3476(16)30683-7. Abstract OBJECTIVES: To evaluate the hepatocellular carcinoma (HCC) risk in Alaska Native children and young adults with hepatitis B virus (HBV). STUDY DESIGN: Published on: Aug-2016 Read more	Cognitive Abilities of Children With Neurological and Liver Forms of Wilson's Disease http://www.ncbi.nlm.nih.gov/pubmed/27482767 Favre E, Lion-François L, Canton M, Vanlemmens C, Bonneton M, Bouillet L, Brunet AS, Lachaux A. J Pediatr Gastroenterol Nutr. 2016 Jul 30. Abstract Published on: Jul-2016 Read more
Prevalence and Significance of Autoantibodies in Children with Acute Liver Failure http://www.ncbi.nlm.nih.gov/pubmed/27496798 Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH; Pediatric Acute Liver Failure Study Group. J Pediatr Gastroenterol Nutr. 2016 Aug 4. Abstract OBJECTIVES: The purpose of this study is to estimate autoantibody (autoAB) frequency, clinical characteristics and 21 day outcome of participants in the Pediatric Acute Liver Failure Study Group (PALFSG) by ANA, SMA and LKM antibody status. METHODS: AutoAB were determined at local and/or central laboratories. Subjects were assigned to autoimmune hepatitis (AIH), indeterminate and other diagnoses groups. RESULTS: Published on: Aug-2016 Read more	Prevalence, Clinical Profile and Outcome of Ascitic Fluid Infection in Children With Liver Disease http://www.ncbi.nlm.nih.gov/pubmed/27482766 . Srivastava A, Malik R, Bolia R, Yachha SK, Poddar U. J Pediatr Gastroenterol Nutr. 2016 Jul 30. Abstract OBJECTIVES: Pediatric literature on spontaneous bacterial peritonitis (SBP) is limited. We evaluated the prevalence, subtypes, clinical profile and effect on outcome of ascitic fluid infection (AFI) in children with liver disease. METHODS: Children with liver disease related ascites and subjected to paracentesis were classified as No-AFI and AFI (SBP, culture negative neutrocytic ascites [CNNA] and monomicrobial non-neutrocytic bacterascites). Clinical and laboratory parameters, in-hospital mortality and outcome in follow-up were noted. RESULTS: Published on: Jul-2016 Read more
Hepatic Inflammation May Influence Liver Stiffness Measurements By Transient Elastography in Children and Young Adults http://www.ncbi.nlm.nih.gov/pubmed/27540711 Raizner A, Shillingford N, Mitchell PD, Harney S, Raza R, Serino J, Jonas MM, Lee CK. J Pediatr Gastroenterol Nutr. 2016 Aug 18. Abstract OBJECTIVES: Transient elastography (TE) measures liver stiffness to assess fibrosis. Studies in adults have shown that inflammation increases stiffness, leading to an overestimation of fibrosis. We investigated the contribution of inflammation to liver stiffness measurements (LSM) in children/ young adults. METHODS: Published on: Aug-2016 Read more	Pediatric NAFLD: the Future role of Patient-Tailored Probiotics Therapy http://www.ncbi.nlm.nih.gov/pubmed/27380600 Putignani L, Alisi A, Nobili V. J Pediatr Gastroenterol Nutr. 2016 Jul;63 Suppl 1:S6-8. doi: 10.1097/MPG.0000000000001220 Abstract PURPOSE OF REVIEW: Clinical evidence of the use of probiotics in pediatric NAFLD, framed within gut microbiota response, is herein discussed. RECENT FINDINGS: The assistance of a new microbiological approach in probiotics' design is playing a central role in NAFLD clinical management. Experimental studies demonstrated the effect of gut microbiota manipulation in NAFLD and recent clinical evidence reported their beneficial effect in pediatric patients. SUMMARY: Published on: Jul-2016 Read more

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