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Hepatic Inflammation May Influence Liver Stiffness Measurements By Transient Elastography in Children and Young Adults http://www.ncbi.nlm.nih.gov/pubmed/27540711 Raizner A, Shillingford N, Mitchell PD, Harney S, Raza R, Serino J, Jonas MM, Lee CK. J Pediatr Gastroenterol Nutr. 2016 Aug 18. Abstract OBJECTIVES: Transient elastography (TE) measures liver stiffness to assess fibrosis. Studies in adults have shown that inflammation increases stiffness, leading to an overestimation of fibrosis. We investigated the contribution of inflammation to liver stiffness measurements (LSM) in children/ young adults. METHODS: Published on: Aug-2016 Read more	Pediatric NAFLD: the Future role of Patient-Tailored Probiotics Therapy http://www.ncbi.nlm.nih.gov/pubmed/27380600 Putignani L, Alisi A, Nobili V. J Pediatr Gastroenterol Nutr. 2016 Jul;63 Suppl 1:S6-8. doi: 10.1097/MPG.0000000000001220 Abstract PURPOSE OF REVIEW: Clinical evidence of the use of probiotics in pediatric NAFLD, framed within gut microbiota response, is herein discussed. RECENT FINDINGS: The assistance of a new microbiological approach in probiotics' design is playing a central role in NAFLD clinical management. Experimental studies demonstrated the effect of gut microbiota manipulation in NAFLD and recent clinical evidence reported their beneficial effect in pediatric patients. SUMMARY: Published on: Jul-2016 Read more
Metabolic Liver Diseases Presenting as Acute Liver Failure in Children http://www.ncbi.nlm.nih.gov/pubmed/27395834 Alam S, Lal B. Indian Pediatr. 2016 Aug 8;53(8):695-701. Epub 2016 Jun 1. Abstract CONTEXT: Suspecting metabolic liver disease in an infant or young child with acute liver failure, and a protocol-based workup for diagnosis is the need of the hour. EVIDENCE ACQUISITION: Data over the last 15 years was searched through Pubmed using the keywords Metabolic liver disease and Acute liver failure with emphasis on Indian perspective. Those published in English language where full text was retrievable were included for this review. RESULTS: Published on: Aug-2016 Read more	Oral Tocofersolan Corrects or Prevents Vitamin E Deficiency in Children with Chronic Cholestasis http://www.ncbi.nlm.nih.gov/pubmed/27429423 Thébaut A, Nemeth A, Le Mouhaër J, Scheenstra R, Baumann U, Koot B, Gottrand F, Houwen R, Monard L, de Micheaux SL, Habes D, Jacquemin E. J Pediatr Gastroenterol Nutr. 2016 Jul 16. Abstract BACKGROUND/AIMS: d-alpha-tocopheryl polyethylene glycol 1000 succinate (Tocofersolan, Vedrop), has been developed in Europe to provide an orally bioavailable source of vitamin E in children with cholestasis. The aim was to analyze the safety/efficacy of Vedrop in a large group of children with chronic cholestasis. METHODS: Published on: Jul-2016 Read more
In Children with Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but does not Reduce Disease Activity Scores http://www.ncbi.nlm.nih.gov/pubmed/27569726 Schwimmer JB, Lavine JE, Wilson LA, Neuschwander-Tetri BA, Xanthakos SA, Kohli R, Barlow SE, Vos MB, Karpen SJ, Molleston JP, Whitington PF, Rosenthal P, Jain AK, Murray KF, Brunt EM, Kleiner DE, Van Natta ML, Clark JM, Tonascia J, Doo E; NASH CRN. Gastroenterology. 2016 Aug 25. Abstract BACKGROUND & AIMS: No treatment for nonalcoholic fatty liver disease (NAFLD) has been approved by regulatory agencies. We performed a randomized controlled trial to determine whether 52 weeks of cysteamine bitartrate delayed release (CBDR) reduces the severity of liver disease in children with NAFLD. METHODS: Published on: Aug-2016 Read more	Guideline for the Evaluation of Cholestatic Jaundice in Infants http://www.ncbi.nlm.nih.gov/pubmed/27429428 Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). awaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, McLin VA, Molleston JP, Neimark E, Ng VL, Karpen SJ. J Pediatr Gastroenterol Nutr. 2016 Jul 16 Abstract Published on: Jul-2016 Read more
Cognitive Abilities of Children With Neurological and Liver Forms of Wilson's Disease http://www.ncbi.nlm.nih.gov/pubmed/27482767 Favre E, Lion-François L, Canton M, Vanlemmens C, Bonneton M, Bouillet L, Brunet AS, Lachaux A. J Pediatr Gastroenterol Nutr. 2016 Jul 30. Abstract Published on: Jul-2016 Read more	Incidence of Primary Mitochondrial Disease in Children Presenting With Acute Liver Failure Under 2 Years of Age http://www.ncbi.nlm.nih.gov/pubmed/27482763 McKiernan P, Ball S, Santra S, Foster K, Fratter C, Poulton J, Craig K, McFarland R, Rahman S, Hargreaves I, Gupte G, Sharif K, Taylor RW. J Pediatr Gastroenterol Nutr. 2016 Jul 30 Abstract Mitochondrial liver disease (MLD), and in particular mitochondrial DNA (mtDNA) depletion syndrome (MDS) is an important cause of acute liver failure (ALF) in infancy. Early and accurate diagnosis is important since liver transplantation (LT) is often contraindicated. It is unclear which methods are the best to diagnose MLD in the setting of ALF. OBJECTIVE: To determine the incidence of MLD in children under two with ALF and the utility of routine investigations to detect MLD. METHODS: Published on: Jul-2016 Read more
Prevalence, Clinical Profile and Outcome of Ascitic Fluid Infection in Children With Liver Disease http://www.ncbi.nlm.nih.gov/pubmed/27482766 . Srivastava A, Malik R, Bolia R, Yachha SK, Poddar U. J Pediatr Gastroenterol Nutr. 2016 Jul 30. Abstract OBJECTIVES: Pediatric literature on spontaneous bacterial peritonitis (SBP) is limited. We evaluated the prevalence, subtypes, clinical profile and effect on outcome of ascitic fluid infection (AFI) in children with liver disease. METHODS: Children with liver disease related ascites and subjected to paracentesis were classified as No-AFI and AFI (SBP, culture negative neutrocytic ascites [CNNA] and monomicrobial non-neutrocytic bacterascites). Clinical and laboratory parameters, in-hospital mortality and outcome in follow-up were noted. RESULTS: Published on: Jul-2016 Read more	Biliary Dyskinesia in Children: A Systematic Review http://www.ncbi.nlm.nih.gov/pubmed/27472474 Santucci N, Hussain SZ, Harmon CM, Schiavo JH, Hyman PE. J Pediatr Gastroenterol Nutr. 2016 Jul 28. Abstract OBJECTIVES: Published on: Jul-2016 Read more

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