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Prevalence and Significance of Autoantibodies in Children With Acute Liver Failure https://www.ncbi.nlm.nih.gov/pubmed/27496798 Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH; Pediatric Acute Liver Failure Study Group.. J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):210-217. Abstract OBJECTIVES: The purpose of the present study is to estimate autoantibody (auto-AB) frequency, clinical characteristics, and 21-day outcome of participants in the Pediatric Acute Liver Failure Study Group (PALFSG) by antinuclear antibody, smooth muscle antibody, and liver-kidney microsomal (LKM) antibody status. METHODS: Auto-ABs were determined at local and/or central laboratories. Subjects were assigned to autoimmune hepatitis (AIH), indeterminate, and other diagnoses groups. RESULTS: Published on: Feb-2017 Read more	Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach. https://www.ncbi.nlm.nih.gov/pubmed/27028797 Del Chierico F, Nobili V, Vernocchi P, Russo A, Stefanis C, Gnani D, Furlanello C, Zandonà A, Paci P, Capuani G, Dallapiccola B, Miccheli A, Alisi A, Putignani L. Hepatology. 2017 Feb;65(2):451-464. doi: 10.1002/hep.28572. Abstract Published on: Jan-2017 Read more
Pediatric acute liver failure of undetermined cause: A research workshop https://www.ncbi.nlm.nih.gov/pubmed/27862115 Alonso EM, Horslen SP, Behrens EM, Doo E. Hepatology. 2017 Mar;65(3):1026-1037. Abstract Published on: Feb-2017 Read more	Five-year histological and serological follow-up of operationally tolerant pediatric liver transplant recipients enrolled in WISP-R. https://www.ncbi.nlm.nih.gov/pubmed/27302659 Feng S, Demetris AJ, Spain KM, Kanaparthi S, Burrell BE, Ekong UD, Alonso EM, Rosenthal P, Turka LA, Ikle D, Tchao NK. Hepatology. 2017 Feb;65(2):647-660. doi: 10.1002/hep.28681. Abstract Published on: Jan-2017 Read more
Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents https://www.ncbi.nlm.nih.gov/pubmed/28230607 Famouri F, Shariat Z, Hashemipour M, Keikha M, Kelishadi R. J Pediatr Gastroenterol Nutr. 2017 Mar;64(3):413-417. Abstract OBJECTIVES: This study aims to evaluate the effects of some probiotics on sonographic and biochemical nonalcoholic fatty liver disease(NAFLD). METHODS: This randomized triple-blind trial was conducted among 64 obese children with sonographic NAFLD. They were randomly allocated to receive probiotic capsule (containing Lactobacillus acidophilus ATCC B3208, 3 × 10 colony forming units [CFU]; Bifidobacterium lactis DSMZ 32269, 6 × 10 CFU; Bifidobacterium bifidum ATCC SD6576, 2 × 10 CFU; Lactobacillus rhamnosus DSMZ 21690, 2 × 10 CFU) or placebo for 12 weeks. RESULTS: Published on: Feb-2017 Read more	Lactate and Lactate: Pyruvate Ratio in the Diagnosis and Outcomes of Pediatric Acute Liver Failure https://www.ncbi.nlm.nih.gov/pubmed/28088395 Feldman AG, Sokol RJ, Hardison RM, Alonso EM, Squires RH, Narkewicz MR; Pediatric Acute Liver Failure Study Group.J Pediatr. 2017 Jan 12. pii: S0022-3476(16)31430-5. doi: 10.1016/j.jpeds.2016.12.031. Abstract OBJECTIVES: To assess the accuracy of blood lactate and lactate: pyruvate molar ratio (L:P) as a screen for mitochondrial, respiratory chain, or fatty acid oxidation disorders in children with pediatric acute liver failure (PALF); to determine whether serum lactate ≥ 2.5 mmol/L or L:P ≥ 25 correlated with biochemical variables of clinical severity; and to determine whether lactate or L:P is associated with clinical outcome at 21 days. STUDY DESIGN: Published on: Jan-2017 Read more
MRI for Quantification of Liver and Cardiac Iron in Thalassemia Major Patients: Pilot Study in Indian Population. https://www.ncbi.nlm.nih.gov/pubmed/28233255 Mandal S, Sodhi KS, Bansal D, Sinha A, Bhatia A, Trehan A, Khandelwal N. Indian J Pediatr. 2017 Feb 24. doi: 10.1007/s12098-017-2310-8. Abstract OBJECTIVE: To evaluate Magnetic resonance imaging (MRI) as a tool to quantify liver and cardiac iron in Indian population with thalassemia major, and correlate liver and cardiac iron values with that of serum ferritin (SF). METHODS: Published on: Feb-2017 Read more	Hospitalizations for Respiratory Syncytial Virus and Vaccine-Preventable Infections in the First 2 Years After Pediatric Liver Transplant https://www.ncbi.nlm.nih.gov/pubmed/28088400 Feldman AG, Sundaram SS, Beaty BL, Kempe A. J Pediatr. 2017 Jan 11. pii: S0022-3476(16)31418-4. doi: 10.1016/j.jpeds.2016.12.021. Abstract OBJECTIVES: To examine in liver transplant recipients at centers participating in the Pediatric Health Information System dataset the number of hospitalizations for respiratory syncytial virus (RSV) and vaccine-preventable infections (VPIs) in the first 2 years after transplantation, morbidity and mortality associated with these hospitalizations, and costs associated with these hospitalizations. STUDY DESIGN: Published on: Jan-2017 Read more
Prevalence, Clinical Profile, and Outcome of Ascitic Fluid Infection in Children With Liver Disease https://www.ncbi.nlm.nih.gov/pubmed/27482766 Srivastava A, Malik R, Bolia R, Yachha SK, Poddar U. J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):194-199. Abstract OBJECTIVES: Pediatric literature on spontaneous bacterial peritonitis (SBP) is limited. We evaluated the prevalence, subtypes, clinical profile, and effect on outcome of ascitic fluid infection (AFI) in children with liver disease. METHODS: Children with liver disease-related ascites and subjected to paracentesis were classified as no-AFI and AFI (SBP, culture-negative neutrocytic ascites [CNNA], and monomicrobial non-neutrocytic bacterascites). Clinical and laboratory parameters, in-hospital mortality, and outcome in follow-up were noted. RESULTS: Published on: Jan-2017 Read more	NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty LiverDisease in Children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology https://www.ncbi.nlm.nih.gov/pubmed/28107283 Vos MB, Abrams SH, Barlow SE, Caprio S, Daniels SR, Kohli R, Mouzaki M, Sathya P, Schwimmer JB, Sundaram SS, Xanthakos SA. J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):319-334. doi: 10.1097/MPG.0000000000001482. Abstract Published on: Jan-2017 Read more

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