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Correlation of Transient Elastography With Severity of Cystic Fibrosis Related Liver Disease https://www.ncbi.nlm.nih.gov/pubmed/27782957 Aqul A, Jonas MM, Harney S, Raza R, Sawicki GS, Mitchell PD, Fawaz R. J Pediatr Gastroenterol Nutr. 2016 Oct 25. Abstract OBJECTIVE: To evaluate whether liver stiffness measurement (LSM), determined by transient elastography (TE), correlates with presence and severity of liver disease (LD) in children and young adults with cystic fibrosis (CF). METHODS: Subjects underwent LSM at routine CF visits. Presence and severity of CFLD was determined by clinical parameters. Subjects were classified as no CFLD, CFLD without portal hypertension (PHTN), and CFLD with PHTN. LSM was compared to AST/platelet ratio index (APRI) as a correlate to severity of CFLD. RESULTS: Published on: Oct-2016 Read more	Complications of Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients; A Systematic Literature Review and Meta-Analysis https://www.ncbi.nlm.nih.gov/pubmed/27663215 Usatin D, Fernandes M, Allen IE, Perito ER, Ostroff J, Heyman MB. J Pediatr. 2016 Sep 20. pii: S0022-3476(16)30733-8. doi: 10.1016/j.jpeds.2016.08.046. Abstract OBJECTIVES: To systematically review risks and summarize reported complication rates associated with the performance of endoscopic retrograde cholangiopancreatography (ERCP) in children during the past 2 decades. STUDY DESIGN: Published on: Sep-2016 Read more
Intensive Care Management of Pediatric Acute Liver Failure https://www.ncbi.nlm.nih.gov/pubmed/27741059 Acute liver failure Lutfi R, Abulebda K, Nitu ME, Molleston JP, Bozic MA, Subbarao G. J Pediatr Gastroenterol Nutr. 2016 Oct 12 Abstract Published on: Oct-2016 Read more	Associations among the Degree of Nonalcoholic Fatty Liver Disease https://www.ncbi.nlm.nih.gov/pubmed/27738602 Metabolic Syndrome, Degree of Obesity in Children, and Parental Obesity. Oh MS, Kim S, Jang JH, Park JY, Kang HS, Lee MS, Kang KS. Pediatr Gastroenterol Hepatol Nutr. 2016 Sep;19(3):199-206. Abstract PURPOSE: To analyze the associations among the degrees of nonalcoholic fatty liver disease (NAFLD) by ultrasonography and metabolic syndrome, degrees of obesity in children, and degrees of parental obesity. METHODS: Published on: Sep-2016 Read more
Outcomes of Children With and Without Hepatic Encephalopathy From the Pediatric Acute Liver Failure Study Group https://www.ncbi.nlm.nih.gov/pubmed/27367788 Ng VL, Li R, Loomes KM, Leonis MA, Rudnick DA, Belle SH, Squires RH; Pediatric Acute Liver Failure Study Group (PALFSG). J Pediatr Gastroenterol Nutr. 2016 Sep;63(3):357-64. doi: 10.1097/MPG.0000000000001178 Abstract OBJECTIVES: Hepatic encephalopathy (HE) is challenging to identify in children with acute liver failure and was not a requirement for enrollment into the Pediatric Acute Liver Failure Study Group (PALFSG). The outcomes of PALFSG participants presenting with and without HE are presented. METHODS: Published on: Sep-2016 Read more	Congenital Vascular Malformations of the Liver: an Association With Trisomy 21. https://www.ncbi.nlm.nih.gov/pubmed/27602703 Burdall OC, Grammatikopoulos T, Sellars M, Hadzic N, Davenport M. J Pediatr Gastroenterol Nutr. 2016 Sep 6. Abstract Published on: Sep-2016 Read more
Long-term Effects of Hepatitis B Immunization of Infants in Preventing Liver Cancer https://www.ncbi.nlm.nih.gov/pubmed/27269245 Chang MH, You SL, Chen CJ, Liu CJ, Lai MW, Wu TC, Wu SF, Lee CM, Yang SS, Chu HC, Wang TE, Chen BW, Chuang WL, Soon MS, Lin CY, Chiou ST, Kuo HS, Chen DS; Taiwan Hepatoma Study Group. Gastroenterology. 2016 Sep;151(3):472-480.e1. doi: 10.1053/j.gastro.2016.05.048. Epub 2016 Jun 4. Abstract BACKGROUND & AIMS: The incidence of hepatocellular carcinoma (HCC) increases with age, but protective antibody responses decrease with time after infants are immunized against hepatitis B virus (HBV). We investigated whether immunization of infants against HBV prevents their developing HCC as adults. We also searched for strategies to maximize the cancer-preventive effects. METHODS: Published on: Sep-2016 Read more	Family Impact and Infant Emotional Outcomes Following Diagnosis of Serious Liver Disease or Transplantation in Infancy Bowden MR, Ee LC, Krishnan U, O'Loughlin EV, Hardikar W, Carmody D, Hainsworth C, Jermyn V, Lee MM, Sawyer J, Stormon M, Holmes K, Lemberg DA, Day AS, Paul C, Hazell P. J Pediatr Gastroenterol Nutr. 2016 Sep 24. Abstract OBJECTIVES: Research is lacking into the emotional effects on families of serious chronic illness in infants. We examined the impact of the diagnosis of serious liver disease in infants upon parent psychological symptoms and family functioning. We hypothesized that parent psychological symptoms, family functioning and father engagement will predict infant emotional outcomes. METHODS: Published on: Sep-2016 Read more
The dendritic cell-Th17-macrophage axis controls cholangiocyte injury and disease progression in murine and human biliary atresia https://www.ncbi.nlm.nih.gov/pubmed/27641439 Lages CS, Simmons J, Maddox A, Jones K, Karns R, Sheridan R, Shanmukhappa SK, Mohanty S, Kofron M, Russo P, Wang YH, Chougnet C, Miethke AG. Hepatology. 2016 Sep 19. doi: 10.1002/hep.28851. Abstract Published on: Sep-2016 Read more	Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease https://www.ncbi.nlm.nih.gov/pubmed/27501738 Sundaram SS, Halbower A, Pan Z, Robbins K, Capocelli KE, Klawitter J, Shearn CT, Sokol RJ. J Hepatol. 2016 Sep;65(3):560-9. doi: 10.1016/j.jhep.2016.04.010. Epub 2016 Aug 5. Abstract BACKGROUND & AIMS: Oxidative stress is proposed as a central mediator in NAFLD pathogenesis, but the specific trigger for reactive oxygen species generation has not been clearly delineated. In addition, emerging evidence shows that obesity related obstructive sleep apnea (OSA) and nocturnal hypoxia are associated with NAFLD progression in adults. The aim of this study was to determine if OSA/nocturnal hypoxia-induced oxidative stress promotes the progression of pediatric NAFLD. METHODS: Published on: Sep-2016 Read more

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