https://www.ncbi.nlm.nih.gov/pubmed/31436896 Liver transplant
Clin Transplant. 2019 Aug 22. doi: 10.1111/ctr.13698. [Epub ahead of print]
Efficacy and safety of tacrolimus in de novo pediatric transplant recipients randomized to receive immediate- or prolonged-release tacrolimus.
Vondrak K1, Parisi F2, Dhawan A3, Grenda R4, Webb NJ5, Marks SD6, Debray D7, Holt RC8, Lachaux A9, Kelly D10, Kazeem G11,12, Undre N11.
Abstract
BACKGROUND AND AIMS:
This multicenter trial compared immediate-release tacrolimus (IR-T) versus prolonged-release tacrolimus (PR-T) in de novo kidney-, liver-, and heart-transplant recipients aged <16 years. Each formulation had similar pharmacokinetic (PK) profiles. Follow-up efficacy and safety results are reported herein.
MATERIALS AND METHODS:
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https://www.ncbi.nlm.nih.gov/pubmed/31468295
Hepatol Int. 2019 Aug 29. doi: 10.1007/s12072-019-09979-8. [Epub ahead of print]
Pediatric non-cirrhotic portal fibrosis: role of endoscopic management in determining long-term outcome.
Prasad D1, Sen Sarma M2, Yachha SK1, Srivastava A1, Poddar U1.
Abstract
AIMS:
Non-cirrhotic portal fibrosis (NCPF) is a rare cause of pediatric portal hypertension. There is abundant literature in adults but paucity of data in children. We aimed to evaluate and compare the endoscopic and long-term outcomes of children with NCPF.
METHODS:
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https://www.ncbi.nlm.nih.gov/pubmed/31437071 Cholestasis
Fetal Pediatr Pathol. 2019 Aug 22:1-17. doi: 10.1080/15513815.2019.1652376. [Epub ahead of print]
Non Syndromic Paucity of Interlobular Bile Ducts in Children - A Clinicopathological Study.
Mohanty S1, Das K2, Anne Correa MM1.
Abstract
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https://www.ncbi.nlm.nih.gov/pubmed/31471942 Liver transplant
Pediatr Transplant. 2019 Aug 31:e13565. doi: 10.1111/petr.13565. [Epub ahead of print]
Monitoring intra-abdominal pressure after liver transplantation in children.
Deindl P1, Wagner J1, Herden U2, Schulz-Jürgensen S3, Schild R4, Vettorazzi E5, Bergers M1, Keck M6, Singer D1, Fischer L2, Herrmann J7.
Abstract
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https://www.ncbi.nlm.nih.gov/pubmed/31444465 NAFLD
Eur J Clin Nutr. 2019 Aug 23. doi: 10.1038/s41430-019-0493-y. [Epub ahead of print]
Vitamin D deficiency: prevalence and association with liver disease severity in pediatric nonalcoholic fatty liver disease.
Yodoshi T1, Orkin S1, Arce-Clachar AC1,2, Bramlage K1, Liu C3, Fei L2,3, El-Khider F4, Dasarathy S4, Xanthakos SA1,2, Mouzaki M5,6.
Abstract
BACKGROUND/OBJECTIVES:
To determine associations between serum 25-hydroxyvitamin D (25(OH)-D) concentrations and histologic nonalcoholic fatty liver disease (NAFLD) severity.
SUBJECTS/METHODS:
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https://www.ncbi.nlm.nih.gov/pubmed/31474443 Autoimmune hepatitis
Hepatobiliary Pancreat Dis Int. 2019 Aug 24. pii: S1499-3872(19)30176-6. doi: 10.1016/j.hbpd.2019.08.004. [Epub ahead of print]
Acute onset of autoimmune hepatitis in children and adolescents.
Smolka V1, Tkachyk O2, Ehrmann J3, Karaskova E2, Zapalka M2, Volejnikova J2.
Abstract
BACKGROUND:
Autoimmune hepatitis (AIH) is a rare progressive liver disease, which manifests as acute hepatitis in 40%-50% of pediatric cases. This refers predominantly to spontaneous exacerbations of previously unrecognized subclinical AIH with laboratory and histological signs of chronic hepatitis, or to acute exacerbations of known chronic disease. Only a few of these patients fulfill criteria for acute liver failure (ALF).
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https://www.ncbi.nlm.nih.gov/pubmed/31450232 cholestasis
Pediatr Res. 2019 Aug 26. doi: 10.1038/s41390-019-0548-8. [Epub ahead of print]
Molecular findings in children with inherited intrahepatic cholestasis.
Wang NL1, Lu Y1, Gong JY2, Xie XB1, Lin J3, Abuduxikuer K1, Zhang MH2, Wang JS4.
Abstract
BACKGROUND:
Genetic defects account for a substantial proportion of pediatric cholestasis. This study explored the molecular findings in a large cohort of Chinese patients with inherited cholestasis.
METHODS:
Between January 2012 and June 2016, 809 Chinese pediatric patients with suspected inherited intrahepatic cholestasis were evaluated by Sanger sequencing and/or panel sequencing.
RESULTS:
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https://www.ncbi.nlm.nih.gov/pubmed/31409456 Primary sclerosing cholangitis
Pediatr Neonatol. 2019 Aug;60(4):396-404. doi: 10.1016/j.pedneo.2018.09.007. Epub 2018 Oct 2.
Characteristics and outcome of primary sclerosing cholangitis associated with inflammatory bowel disease in Asian children.
Lee WS1, Karthik SV2, Ng RT3, Ong SY3, Ong C4, Chiou FK4, Wong SY3, Quak SH5, Aw MM5.
Abstract
BACKGROUND:
Current knowledge on the clinical features and natural history of childhood primary sclerosing cholangitis - inflammatory bowel disease in Asia is limited. We described the presenting features and natural history of primary sclerosing cholangitis-inflammatory bowel disease seen in a cohort of Southeast Asian children.
METHODS:
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https://www.ncbi.nlm.nih.gov/pubmed/31460577 Autoimmune liver disease
Arq Gastroenterol. 2019 Aug 13;56(2):146-150. doi: 10.1590/S0004-2803.201900000-29.
HLA-DRB1 GENE POLYMORPHISMS IN PEDIATRIC PATIENTS WITH TYPE 1 AUTOIMMUNE HEPATITIS AND TYPE 1 AUTOIMMUNE HEPATITIS OVERLAP SYNDROME WITH AUTOIMMUNE CHOLANGITIS.
Nunes MEG1, Rosa DV1, Fagundes EDT2, Ferreira AR2, Miranda DM1, Ferri Liu PM2.
Abstract
BACKGROUND:
Autoimmune hepatitis (AIH) is a rare chronic inflammatory liver disease associated with a loss of immunological tolerance to self-antigens. Susceptibility to AIH is partially determined by the presence of genes related to human leukocyte antigen (HLA), mainly allelic variants of DRB1.
OBJECTIVE:
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https://www.ncbi.nlm.nih.gov/pubmed/31410937 Biliary atresia
Pediatr Transplant. 2019 Aug 13:e13569. doi: 10.1111/petr.13569. [Epub ahead of print]
A paradigm shift in the intention-to-transplant children with biliary atresia: Outcomes of 101 cases and a review of the literature.
de Ville de Goyet Prof J1, Grimaldi C Dr2, Tuzzolino F3, di Francesco F Dr1.
Abstract
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