Event Videos

Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with Biliary Atresia

http://www.ncbi.nlm.nih.gov/pubmed/25419594
Venkat VL1, Shneider BL, Magee JC, Turmelle Y, Arnon R, Bezerra JA, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston J, Murray KF, Ng VL,Raghunathan T, Rosenthal P, Schwartz K, Sherker AH, Sokol RJ, Teckman J, Wang K, Whitington PF, Heubi JE; Childhood Liver Disease Research and Education Network.

Abstract

OBJECTIVE:
Fat-soluble vitamin (FSV) deficiency is a well-recognized consequence of cholestatic liver disease and reduced intestinal intraluminal bile acid. We hypothesized that serum bile acid (SBA) would predict biochemical FSV deficiency better than serum total bilirubin (TB) level in infants with biliary atresia.

METHODS:

Published on: 
Dec-2014
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γ-Glutamyl transpeptidase level as a screening marker among diverse etiologies of infantile intrahepatic cholestasis

http://www.ncbi.nlm.nih.gov/pubmed/25141230
Lu FT1, Wu JF, Hsu HY, Ni YH, Chang MH, Chao CI, Chen HL.

Abstract

OBJECTIVES:
Low γ-glutamyl transpeptidase (GGT) level is an important marker for progressive familial intrahepatic cholestasis, yet the cutoff level and clinical application is not well defined. This study aimed to evaluate the role of GGT as a screening marker among diverse etiologies of infantile cholestasis.

METHODS:

Published on: 
Dec-2014
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Points to be considered when applying FibroScan S probe in children with biliary atresia

http://www.ncbi.nlm.nih.gov/pubmed/25003372
Kim S, Kang Y, Lee MJ, Kim MJ, Han SJ, Koh H.

Abstract

OBJECTIVES:
With the introduction of smaller probes (S1, S2), the use of transient elastography has been expanded to children. Accordingly, we aimed to address points of consideration in probe choice and interpretation of measured liver stiffness by applying and comparing FibroScan S and M probes in biliary atresia.

METHODS:

Published on: 
Nov-2014
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Clues for minimal hepatic encephalopathy in children with noncirrhotic portal hypertension

http://www.ncbi.nlm.nih.gov/pubmed/25141228
D'Antiga L1, Dacchille P, Boniver C, Poledri S, Schiff S, Zancan L, Amodio P.

Abstract

OBJECTIVE:
In children with noncirrhotic extrahepatic portal vein obstruction (EHPVO), minimal hepatic encephalopathy (MHE) was reported in a few series, but neither is it routinely investigated nor does consensus about its diagnosis exist. In this prospective observational study we aimed at detecting the prevalence of MHE in children with EHPVO and providing a practical diagnostic protocol.

METHODS:

Published on: 
Dec-2014
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Analysis of viral testing in nonacetaminophen pediatric acute liver failure

http://www.ncbi.nlm.nih.gov/pubmed/25340974

Schwarz KB, Dell Olio D, Lobritto SJ, Lopez MJ, Rodriguez-Baez N, Yazigi NA, Belle SH, Zhang S, Squires RH; Pediatric Acute Liver Failure Study Group. Analysis of viral testing in non-acetaminophen pediatric acute liver failure. J Pediatr Gastroenterol Nutr. 2014 Nov; 59(5): 616-23.

Abstract

OBJECTIVE:
Viral infections are often suspected to cause pediatric acute liver failure (PALF), but large-scale studies have not been performed. We analyzed the results of viral testing among nonacetaminophen PALF study participants.

METHODS:

Published on: 
Nov-2014
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Progressive familial Intrahepatic Cholestasis

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647530/

Anne Davit-Spraul, Emmanuel Gonzales,Christiane Baussan and Emmanuel Jacquemin

Abstract

Progressive familial intrahepatic cholestasis (PFIC) refers to heterogeneous group of autosomal recessive disorders of childhood that disrupt bile formation and present with cholestasis of hepatocellular origin. The exact prevalence remains unknown, but the estimated incidence varies between 1/50,000 and 1/100,000 births.

Published on: 
Jan-2009
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