Event Videos

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647530/

Anne Davit-Spraul, Emmanuel Gonzales,Christiane Baussan and Emmanuel Jacquemin

Abstract

Progressive familial intrahepatic cholestasis (PFIC) refers to heterogeneous group of autosomal recessive disorders of childhood that disrupt bile formation and present with cholestasis of hepatocellular origin. The exact prevalence remains unknown, but the estimated incidence varies between 1/50,000 and 1/100,000 births.

Published on: 
Jan-2009

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122094/

Ramaswamy Ganesh, Natarajan Suresh, Malathi Sathiyasekeran, Priya Ramachandran

Abstract

Biliary diversion offers a potential option for intractable pruritus in children with chronic cholestatic disorders. Progressive familial intrahepatic cholestasis (PFIC) is an inherited disorder of impaired bile acid transport and excretion, which presents with jaundice and pruritus in the first few months of life and progresses to cirrhosis by infancy or adolescence. We report a child with PFIC type 1 who underwent internal biliary diversion for intractable pruritus and was relieved of his symptoms.

Published : The Saudi Journal Gastroenterology 2011 May-Jun; 17(3): 212–214.

Published on: 
Jun-2011

http://www.ncbi.nlm.nih.gov/pubmed/25003372
Kim S, Kang Y, Lee MJ, Kim MJ, Han SJ, Koh H.

Abstract

OBJECTIVES:
With the introduction of smaller probes (S1, S2), the use of transient elastography has been expanded to children. Accordingly, we aimed to address points of consideration in probe choice and interpretation of measured liver stiffness by applying and comparing FibroScan S and M probes in biliary atresia.

METHODS:

Published on: 
Nov-2014

http://www.ncbi.nlm.nih.gov/pubmed/25340974

Schwarz KB, Dell Olio D, Lobritto SJ, Lopez MJ, Rodriguez-Baez N, Yazigi NA, Belle SH, Zhang S, Squires RH; Pediatric Acute Liver Failure Study Group. Analysis of viral testing in non-acetaminophen pediatric acute liver failure. J Pediatr Gastroenterol Nutr. 2014 Nov; 59(5): 616-23.

Abstract

OBJECTIVE:
Viral infections are often suspected to cause pediatric acute liver failure (PALF), but large-scale studies have not been performed. We analyzed the results of viral testing among nonacetaminophen PALF study participants.

METHODS:

Published on: 
Nov-2014

What is PFIC ?

PFIC as the name stands for is a rare progressive disorder affecting liver due to defect in secretion of bile. As an inherited inability to secrete bile , it accumulates in the liver causing damage and ultimately end stage liver failure.

 

PFIC is Autosomal recessive disorder and can affect both males and females equally. It is a rare disease affecting about 1 per 1,00,000 births around the world.

CLF Intro movie

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