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Treatment of bile acid amidation defects with glycocholic acid http://www.ncbi.nlm.nih.gov/pubmed/25163551 Heubi JE, Setchell KD, Jha P, Buckley D, Zhang W, Rosenthal P, Potter C, Horslen S, Suskind D. Treatment of bile acid amidation defects with glycocholic acid. Hepatology. 2015 Jan; 61(1):268-74. Abstract Published on: Jan-2015 Read more	Parenteral nutrition-associated liver injury and increased GRP94 expression prevented by ω-3 fish oil-based lipid emulsion supplementation http://www.ncbi.nlm.nih.gov/pubmed/25199039 Zhu X1, Xiao Z, Chen X, Li Y, Zhang X, Xu Y, Feng X, Wang J. Abstract OBJECTIVE: Parenteral nutrition in infants with gastrointestinal disorders can be lifesaving, but it is also associated with parenteral nutrition-associated liver disease. We investigated the effects of incorporating ω-3 fish oil in a parenteral nutrition mixture on signs of parenteral nutrition-associated liver disease and explored the mechanism involved in this process. METHODS: Published on: Dec-2014 Read more
HEPATICON 2015 Hepaticon 2015 was held at Nehru Centre on 10th and 11th January 2015. It was a meeting organized by Children’s Liver Foundation (CLF) and IAP, Mumbai and endorsed by the Indian Association for study of Liver (INASL). The meeting was attended by over 300 delegates from all over the country. The format of the meeting was case discussions interspersed by a few related talks. PG students from all over the country presented cases to a team of 3 panelists who were completely oblivious to the case. The moderators ensured audience participation and good interaction. The National faculty - Dr SK Yachha and Dr Anshu Srivastava from SGPGI, Lucknow, Dr. Read more	Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with Biliary Atresia http://www.ncbi.nlm.nih.gov/pubmed/25419594 Venkat VL1, Shneider BL, Magee JC, Turmelle Y, Arnon R, Bezerra JA, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston J, Murray KF, Ng VL,Raghunathan T, Rosenthal P, Schwartz K, Sherker AH, Sokol RJ, Teckman J, Wang K, Whitington PF, Heubi JE; Childhood Liver Disease Research and Education Network. Abstract OBJECTIVE: Fat-soluble vitamin (FSV) deficiency is a well-recognized consequence of cholestatic liver disease and reduced intestinal intraluminal bile acid. We hypothesized that serum bile acid (SBA) would predict biochemical FSV deficiency better than serum total bilirubin (TB) level in infants with biliary atresia. METHODS: Published on: Dec-2014 Read more
HEPATICON 2015 Presentations Read more	γ-Glutamyl transpeptidase level as a screening marker among diverse etiologies of infantile intrahepatic cholestasis http://www.ncbi.nlm.nih.gov/pubmed/25141230 Lu FT1, Wu JF, Hsu HY, Ni YH, Chang MH, Chao CI, Chen HL. Abstract OBJECTIVES: Low γ-glutamyl transpeptidase (GGT) level is an important marker for progressive familial intrahepatic cholestasis, yet the cutoff level and clinical application is not well defined. This study aimed to evaluate the role of GGT as a screening marker among diverse etiologies of infantile cholestasis. METHODS: Published on: Dec-2014 Read more
Cystic fibrosis: an update for clinicians. Part 2: hepatobiliary and pancreatic manifestations http://www.ncbi.nlm.nih.gov/pubmed/25238538 Ledder O1, Haller W, Couper RT, Lewindon P, Oliver M. Abstract This paper, the second in the series, will build on the first and explore the importance of liver and pancreatic manifestations of cystic fibrosis (CF) and the effect on morbidity and mortality of this multifaceted genetic condition. It will also further develop the critical role of the gastroenterologist as part of the multidisciplinary group of clinicians and allied health staff in the effective management of patients with CF. Published on: Dec-2014	Clues for minimal hepatic encephalopathy in children with noncirrhotic portal hypertension http://www.ncbi.nlm.nih.gov/pubmed/25141228 D'Antiga L1, Dacchille P, Boniver C, Poledri S, Schiff S, Zancan L, Amodio P. Abstract OBJECTIVE: In children with noncirrhotic extrahepatic portal vein obstruction (EHPVO), minimal hepatic encephalopathy (MHE) was reported in a few series, but neither is it routinely investigated nor does consensus about its diagnosis exist. In this prospective observational study we aimed at detecting the prevalence of MHE in children with EHPVO and providing a practical diagnostic protocol. METHODS: Published on: Dec-2014 Read more
Levels of Alkaline Phosphatase and Bilirubin Are Surrogate End Points of Outcomes of Patients With Primary Biliary Cirrhosis: An International Follow-up Study http://www.ncbi.nlm.nih.gov/pubmed/25160979 Lammers WJ1, van Buuren HR1, Hirschfield GM2, Janssen HL3, Invernizzi P4, Mason AL5, Ponsioen CY6, Floreani A7, Corpechot C8, Mayo MJ9, Battezzati PM10, Parés A11, Nevens F12, Burroughs AK13, Kowdley KV14, Trivedi PJ2, Kumagi T15, Cheung A3, Lleo A4, Imam MH16, Boonstra K6, Cazzagon N7,Franceschet I7, Poupon R8, Caballeria L11, Pieri G13, Kanwar PS14, Lindor KD17, Hansen BE18; Global PBC Study Group. Abstract BACKGROUND & AIMS: Published on: Dec-2014 Read more	Short duration of lamivudine for the prevention of hepatitis B virus transmission in pregnancy: lack of potency and selection of resistance mutations http://www.ncbi.nlm.nih.gov/pubmed/24329944 Ayres A1, Yuen L, Jackson KM, Manoharan S, Glass A, Maley M, Yoo W, Hong SP, Kim SO, Luciani F, Bowden DS, Bayliss J, Levy MT, Locarnini SA. Abstract Published on: Nov-2014 Read more

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