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Hepatic steatosis is prevalent in stillborns delivered to women with diabetes mellitus http://www.ncbi.nlm.nih.gov/pubmed/25079479 Patel KR, White FV, Deutsch GH. Hepatic steatosis is prevalent in stillborns delivered to women with diabetes mellitus. J Pediatr Gastroenterol Nutr. 2015 Feb;60(2): 152-8. Abstract OBJECTIVE: Maternal diabetes is a risk factor for pregnancy complications, including stillbirth and macrosomia. Evolving data suggest that diabetes during pregnancy also has long-term consequences for offspring, putting them at risk for obesity and the metabolic syndrome in childhood. Because nonalcoholic fatty liver disease is known to occur in adults and children with insulin resistance, we hypothesized that altered lipid metabolism in fetuses of diabetic mothers may manifest with hepatic steatosis. METHODS: Published on: Feb-2015 Read more	Aspartate aminotransferase to platelet ratio index as a prospective predictor of hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection http://www.ncbi.nlm.nih.gov/pubmed/24995497 Hann HW, Wan S, Lai Y, Hann RS, Myers RE, Patel F, Zhang K, Ye Z, Wang C, Yang H. Aspartate aminotransferase to platelet ratio index as a prospective predictor of hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection. J Gastroenterol Hepatol. 2015 Jan; 30(1):131-8. Abstract BACKGROUND AND AIM: APRI (aspartate aminotransferase [AST] to platelet ratio index) is widely used to assess fibrosis and cirrhosis risk, especially in hepatitis C virus (HCV)-infected patients. Few studies have evaluated APRI and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) risk. Prospective evidence is needed to assess whether APRI predicts HCC risk in HBV patients. METHOD: Published on: Jan-2015 Read more
Chronic hepatitis B virus infection in children and adolescents in Japan http://www.ncbi.nlm.nih.gov/pubmed/25221937 Komatsu H, Inui A, Sogo T, Tsunoda T, Fujisawa T. Chronic hepatitis B virus infection in children and adolescents in Japan. J Pediatr Gastroenterol Nutr. 2015 Jan; 60(1): 99-104. Abstract BACKGROUND: Hepatitis B e antigen (HBeAg) seroconversion is an important event in patients with chronic hepatitis B virus (HBV) infection. This study aimed to clarify the outcome of long-term follow-up of chronic HBV infection and the factors affecting HBeAg seroconversion in children in Japan. METHODS: Published on: Jan-2015 Read more	Major predictors of portal hypertensive enteropathy in patients with liver cirrhosis http://www.ncbi.nlm.nih.gov/pubmed/24988903 Aoyama T, Oka S, Aikata H, Igawa A, Nakano M, Naeshiro N, Yoshida S, Tanaka S, Chayama K. Major predictors of portal hypertensive enteropathy in patients with liver cirrhosis. J Gastroenterol Hepatol. 2015 Jan; 30(1):124-30. Abstract BACKGROUND AND AIM: Portal hypertensive enteropathy (PHE) is acknowledged as a source of bleeding, and predicting its presence has become more important. We assessed PHE using capsule endoscopy (CE) and investigated factors that may predict its presence, including portosystemic shunts (PSs). METHODS: Published on: Jan-2015 Read more
Cost-effective analysis of screening for biliary atresia with the stool color card http://www.ncbi.nlm.nih.gov/pubmed/25221934 Mogul D, Zhou M, Intihar P, Schwarz K, Frick K. Cost-effective analysis of screening for biliary atresia with the stool color card. J Pediatr Gastroenterol Nutr. 2015 Jan; 60(1):91-8. Abstract BACKGROUND: Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease and liver transplantation in the United States. Early diagnosis leads to improved outcomes, but diagnosis is often delayed, leading to increased rates of transplantation and mortality. METHODS: Published on: Jan-2015 Read more	Functional analysis of ABCB4 mutations relates clinical outcomes of progressive familial intrahepatic cholestasis type 3 to the degree of MDR3 floppase activity http://www.ncbi.nlm.nih.gov/pubmed/24594635 Gordo-Gilart R, Andueza S, Hierro L, Martínez-Fernández P, D'Agostino D, Jara P, Alvarez L. Functional analysis of ABCB4 mutations relates clinical outcomes of progressive familial intrahepatic cholestasis type 3 to the degree of MDR3 floppase activity. Gut. 2015 Jan; 64(1):147-55. Abstract OBJECTIVE: Published on: Jan-2015 Read more
Successful use of long-acting octreotide for intractable chronic gastrointestinal bleeding in children http://www.ncbi.nlm.nih.gov/pubmed/25162361 O'Meara M, Cicalese MP, Bordugo A, Ambrosi A, Hadzic N, Mieli-Vergani G. Successful use of long-acting octreotide for intractable chronic gastrointestinal bleeding in children. J Pediatr Gastroenterol Nutr. 2015 Jan; 60(1):48-53. Abstract BACKGROUND AND AIMS: Published on: Jan-2015 Read more	Novel strategies for liver therapy using stem cells http://www.ncbi.nlm.nih.gov/pubmed/25183202 Rashid T, Takebe T, Nakauchi H. Novel strategies for liver therapy using stem cells. Gut. 2015 Jan; 64(1):1-4. Published on: Jan-2015
Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents http://www.ncbi.nlm.nih.gov/pubmed/24989077 Ayonrinde OT, Olynyk JK, Marsh JA, Beilin LJ, Mori TA, Oddy WH, Adams LA. Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents. J Gastroenterol Hepatol. 2015 Jan; 30(1):163-71. Abstract BACKGROUND AND AIM: Nonalcoholic fatty liver disease (NAFLD) and its metabolic risk factors are recognized during childhood and adolescence. Identification of adolescents at risk of NAFLD from childhood anthropometry may expose opportunities to influence the hepatic and metabolic destinies of individuals. We sought associations between NAFLD diagnosed during adolescence and earlier life trajectories of anthropometry, in a population-based cohort of predominantly Caucasian adolescents. METHODS: Published on: Jan-2015 Read more	Prevention of portal hypertension: From variceal development to clinical decompensation http://www.ncbi.nlm.nih.gov/pubmed/24913395 Vorobioff JD, Groszmann RJ. Prevention of portal hypertension: From variceal development to clinical decompensation. Hepatology. 2015 Jan; 61(1):375-81. Abstract Published on: Jan-2015 Read more

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