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Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/pubmed/25729888 Jahnel J, Zöhrer E, Alisi A, Ferrari F, Ceccarelli S, De Vito R, Scharnagl H, Stojakovic T, Fauler G, Trauner M, Nobili V. Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):85-90. Abstract OBJECTIVE: Because the prevalence of obesity in children is increasing, the frequency of pediatric nonalcoholic fatty liver disease(NAFLD) is growing. A reliable noninvasive biomarker for monitoring progression of liver fibrosis would be useful. In cirrhotic personsserum bile acid (BA) levels are significantly elevated. We hypothesized that BA levels and composition in pediatric NAFLD vary depending on the stage of fibrosis. METHODS: Published on: Jul-2015 Read more	Impaired motor competence in children with transplanted liver http://www.ncbi.nlm.nih.gov/pubmed/25658058 Almaas R, Jensen U, Loennecken MC, Tveter AT, Sanengen T, Scholz T, Holm I. Impaired motor competence in children with transplanted liver. J Pediatr Gastroenterol Nutr. 2015 Jun; 60(6):723-8. Abstract OBJECTIVES: Although reduced cognitive function has been demonstrated after liver transplantation in children, few data are available concerning motor competence. METHODS: Thirty-five children ages 4 to 12 years were tested using Movement Assessment Battery for Children (M-ABC) test at a median of 5.1 (3.9-6.9) years after liver transplantation and compared with reference material of healthy children. RESULTS: Published on: Jun-2015 Read more
Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease http://www.ncbi.nlm.nih.gov/pubmed/25529941 ( NAFLD http://www.childrenliverindia.org/diseases/term/34 ) Schwimmer JB, Middleton MS, Behling C, Newton KP, Awai HI, Paiz MN, Lam J, Hooker JC, Hamilton G, Fontanesi J, Sirlin CB. Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease. Hepatology. 2015 Jun;61(6):1887-95. Abstract Published on: Jun-2015 Read more	Family adjustment and parenting stress when an infant has serious liver disease: the Australian experience http://www.ncbi.nlm.nih.gov/pubmed/25643019 Bowden MR, Stormon M, Hardikar W, Ee LC, Krishnan U, Carmody D, Jermyn V, Lee MM, O'Loughlin EV, Sawyer J, Beyerle K, Lemberg DA, Day AS, Paul C, Hazell P. Family adjustment and parenting stress when an infant has serious liver disease: the Australian experience. J Pediatr Gastroenterol Nutr. 2015 Jun; 60(6):717-22. Abstract OBJECTIVES: Parenting stress, problems in family functioning, and lack of fathers' engagement in treatment are associated with poor quality of life in children with chronic illnesses. The aim of the present study was to examine these characteristics in families of infants with serious liver disease in Australia, to inform the provision of mental health care for these families. METHODS: Published on: Jun-2015 Read more
Omega-3 Fatty acids therapy in children with nonalcoholicFatty liver disease: a randomized controlled trial http://www.ncbi.nlm.nih.gov/pubmed/25771388 Janczyk W, Lebensztejn D, Wierzbicka-Rucińska A, Mazur A, Neuhoff-Murawska J, Matusik P, Socha P. Omega-3 Fatty acids therapy in children with nonalcoholicFatty liver disease: a randomized controlled trial. J Pediatr. 2015 Jun;166(6):1358-1363. Abstract OBJECTIVE: To evaluate the efficacy and safety of omega-3 fatty acid supplementation in children with nonalcoholic fatty liver disease(NAFLD). STUDY DESIGN: Published on: Jun-2015 Read more	Impact of parenteral fat composition on cholestasis in preterm infants http://www.ncbi.nlm.nih.gov/pubmed/25633496 Teng J, Arnell H, Bohlin K, Nemeth A, Fischler B. Impact of parenteral fat composition on cholestasis in preterm infants. J Pediatr Gastroenterol Nutr. 2015 Jun; 60(6):702-7. Abstract OBJECTIVES: Parenteral nutrition-associated liver disease (PNALD) is frequently detected in neonatal intensive care units. Parenteral lipid emulsion (PLE) content has been implicated in its pathogenesis. We aimed to study the effect on incidence and outcome of PNALD by replacing soy-based PLE with olive oil-based PLE in a population-based group of preterm infants. METHODS: Published on: Jun-2015 Read more
Fulminant presentation of autoimmune hepatitis: clinical features and early predictors of corticosteroid treatment failure http://www.ncbi.nlm.nih.gov/pubmed/25923939 Mendizabal M, Marciano S, Videla MG, Anders M, Zerega A, Balderramo DC, Tisi Baña MR, Barrabino M, Gil O, Mastai R, Yantorno S, Gadano A, Silva MO. Fulminant presentation of autoimmune hepatitis: clinical features and early predictors of corticosteroid treatment failure. Eur J Gastroenterol Hepatol. 2015 Jun; 27(6):644-8. Abstract BACKGROUND AND AIMS: Classical features of autoimmune hepatitis (AIH) may be altered during the abrupt onset of the disease. Corticosteroid therapy can be life-saving, but its use in the fulminant presentation of AIH (F-AIH) remains controversial. We aimed to assess the clinical features of patients with F-AIH and to describe the role of corticosteroids in this population. PATIENTS AND METHODS: Published on: Jun-2015 Read more	Hepatic progenitor cells in children with chronic hepatitis C: correlation with histopathology, viremia, and treatment response http://www.ncbi.nlm.nih.gov/pubmed/25822865 El-Araby HA, Ehsan NA, Konsowa HA, Abd-Elaati BM, Sira AM. Hepatic progenitor cells in children with chronic hepatitis C: correlation with histopathology, viremia, and treatment response. Eur J Gastroenterol Hepatol. 2015 May; 27(5):561-9. Abstract OBJECTIVE: Hepatic progenitor cells (HPCs) are bipotential stem cells that can differentiate towards the hepatocytic and cholangiocytic lineages. Many studies have investigated HPCs in adults with hepatitis C virus infection; however, none has been carried out in the pediatric population. Therefore, this work aimed to investigate HPCs expansion in children with chronic hepatitis C (CHC) and its correlation with histopathology, viremia, and treatment response. PATIENTS AND METHODS: Published on: May-2015 Read more
Labour productivity losses caused by premature death associated with hepatitis C in Spain. http://www.ncbi.nlm.nih.gov/pubmed/25853930 Oliva-Moreno J, Peña-Longobardo LM, Alonso S, Fernández-Bolaños A, Gutiérrez ML, Hidalgo-Vega Á, de la Fuente E, Fernández-Rodríguez CM. Labour productivity losses caused by premature death associated with hepatitis C in Spain. Eur J Gastroenterol Hepatol. 2015 Jun; 27(6):631-7. Abstract BACKGROUND AND AIMS: Hepatitis C virus (HCV) infection places a huge burden on healthcare systems. There is no study assessing the impact of HCV infection on premature deaths in Spain. The aim of this study was to estimate productivity losses because of premature deaths attributable to hepatitis C occurring in Spain during 2007-2011. MATERIALS AND METHODS: Published on: Jun-2015 Read more	GWAS-Identified Common Variants With Nonalcoholic Fatty Liver Disease in Chinese Children http://www.ncbi.nlm.nih.gov/pubmed/25522307 Shang XR, Song JY, Liu FH, Ma J, Wang HJ. GWAS-Identified Common Variants With Nonalcoholic Fatty Liver Disease in Chinese Children. J Pediatr Gastroenterol Nutr. 2015 May; 60(5):669-74. Abstract OBJECTIVES: Three genome-wide association studies were previously done for nonalcoholic fatty liver disease (NAFLD) among individuals of Western countries and identified several genetic variants associated with NAFLD. The study aimed to identify whether 7 GWAS-identified common variants (GCKR rs780094, PDGFA rs343064, FDFT1 rs2645424, COL13A1 rs1227756, EHBP1L1 rs6591182, NCAN rs2228603, and PNPLA3 rs738409) were associated with NAFLD in Chinese children. METHODS: Published on: May-2015 Read more

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