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Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure http://www.ncbi.nlm.nih.gov/pubmed/25859823 Alonso EM, James LP, Zhang S, Squires RH; Pediatric Acute Liver Failure Study Group. Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):102-7. Abstract OBJECTIVES: Previous studies in patients with acute liver failure identified acetaminophen (APAP) protein adducts in the serum of 12% and 19% of children and adults, respectively, with acute liver failure of indeterminate etiology. This article details the testing of APAP adducts in a subset (n = 393) of patients with varied diagnoses in the Pediatric Acute Liver Failure Study Group (PALFSG). METHODS: Published on: Jul-2015 Read more	Omega-3 Fatty acids therapy in children with nonalcoholicFatty liver disease: a randomized controlled trial http://www.ncbi.nlm.nih.gov/pubmed/25771388 Janczyk W, Lebensztejn D, Wierzbicka-Rucińska A, Mazur A, Neuhoff-Murawska J, Matusik P, Socha P. Omega-3 Fatty acids therapy in children with nonalcoholicFatty liver disease: a randomized controlled trial. J Pediatr. 2015 Jun;166(6):1358-1363. Abstract OBJECTIVE: To evaluate the efficacy and safety of omega-3 fatty acid supplementation in children with nonalcoholic fatty liver disease(NAFLD). STUDY DESIGN: Published on: Jun-2015 Read more
Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension http://www.ncbi.nlm.nih.gov/pubmed/25651489 Childhood Liver Disease Research Network (ChiLDReN). Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension. Extra hepatic portal hypertension Teckman JH, Rosenthal P, Abel R, Bass LM, Michail S, Murray KF, Rudnick DA, Thomas DW, Spino C, Arnon R, Hertel PM, Heubi J, Kamath BM, Karnsakul W, Loomes KM, Magee JC, Molleston JP, Romero R, Shneider BL, Sherker AH, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN). Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):94-101. Abstract OBJECTIVES: Published on: Jul-2015 Read more	Fulminant presentation of autoimmune hepatitis: clinical features and early predictors of corticosteroid treatment failure http://www.ncbi.nlm.nih.gov/pubmed/25923939 Mendizabal M, Marciano S, Videla MG, Anders M, Zerega A, Balderramo DC, Tisi Baña MR, Barrabino M, Gil O, Mastai R, Yantorno S, Gadano A, Silva MO. Fulminant presentation of autoimmune hepatitis: clinical features and early predictors of corticosteroid treatment failure. Eur J Gastroenterol Hepatol. 2015 Jun; 27(6):644-8. Abstract BACKGROUND AND AIMS: Classical features of autoimmune hepatitis (AIH) may be altered during the abrupt onset of the disease. Corticosteroid therapy can be life-saving, but its use in the fulminant presentation of AIH (F-AIH) remains controversial. We aimed to assess the clinical features of patients with F-AIH and to describe the role of corticosteroids in this population. PATIENTS AND METHODS: Published on: Jun-2015 Read more
Bile Ducts in Regenerative Liver Nodules of Alagille Patients Are Not the Result of Genetic Mosaicism http://www.ncbi.nlm.nih.gov/pubmed/25643021 – allagile syndrome Rougemont AL, Alvarez F, McLin VA, Guiochon-Mantel A, Bouligand J, Clément S, Tonson La Tour A, Wildhaber BE, Rubbia-Brandt L, Sartelet H. Bile Ducts in Regenerative Liver Nodules of Alagille Patients Are Not the Result of Genetic Mosaicism. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):91-3. Published on: Jul-2015 Read more	Labour productivity losses caused by premature death associated with hepatitis C in Spain. http://www.ncbi.nlm.nih.gov/pubmed/25853930 Oliva-Moreno J, Peña-Longobardo LM, Alonso S, Fernández-Bolaños A, Gutiérrez ML, Hidalgo-Vega Á, de la Fuente E, Fernández-Rodríguez CM. Labour productivity losses caused by premature death associated with hepatitis C in Spain. Eur J Gastroenterol Hepatol. 2015 Jun; 27(6):631-7. Abstract BACKGROUND AND AIMS: Hepatitis C virus (HCV) infection places a huge burden on healthcare systems. There is no study assessing the impact of HCV infection on premature deaths in Spain. The aim of this study was to estimate productivity losses because of premature deaths attributable to hepatitis C occurring in Spain during 2007-2011. MATERIALS AND METHODS: Published on: Jun-2015 Read more
Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/pubmed/25729888 Jahnel J, Zöhrer E, Alisi A, Ferrari F, Ceccarelli S, De Vito R, Scharnagl H, Stojakovic T, Fauler G, Trauner M, Nobili V. Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):85-90. Abstract OBJECTIVE: Because the prevalence of obesity in children is increasing, the frequency of pediatric nonalcoholic fatty liver disease(NAFLD) is growing. A reliable noninvasive biomarker for monitoring progression of liver fibrosis would be useful. In cirrhotic personsserum bile acid (BA) levels are significantly elevated. We hypothesized that BA levels and composition in pediatric NAFLD vary depending on the stage of fibrosis. METHODS: Published on: Jul-2015 Read more	Impaired motor competence in children with transplanted liver http://www.ncbi.nlm.nih.gov/pubmed/25658058 Almaas R, Jensen U, Loennecken MC, Tveter AT, Sanengen T, Scholz T, Holm I. Impaired motor competence in children with transplanted liver. J Pediatr Gastroenterol Nutr. 2015 Jun; 60(6):723-8. Abstract OBJECTIVES: Although reduced cognitive function has been demonstrated after liver transplantation in children, few data are available concerning motor competence. METHODS: Thirty-five children ages 4 to 12 years were tested using Movement Assessment Battery for Children (M-ABC) test at a median of 5.1 (3.9-6.9) years after liver transplantation and compared with reference material of healthy children. RESULTS: Published on: Jun-2015 Read more
Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease http://www.ncbi.nlm.nih.gov/pubmed/25529941 ( NAFLD http://www.childrenliverindia.org/diseases/term/34 ) Schwimmer JB, Middleton MS, Behling C, Newton KP, Awai HI, Paiz MN, Lam J, Hooker JC, Hamilton G, Fontanesi J, Sirlin CB. Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease. Hepatology. 2015 Jun;61(6):1887-95. Abstract Published on: Jun-2015 Read more	Family adjustment and parenting stress when an infant has serious liver disease: the Australian experience http://www.ncbi.nlm.nih.gov/pubmed/25643019 Bowden MR, Stormon M, Hardikar W, Ee LC, Krishnan U, Carmody D, Jermyn V, Lee MM, O'Loughlin EV, Sawyer J, Beyerle K, Lemberg DA, Day AS, Paul C, Hazell P. Family adjustment and parenting stress when an infant has serious liver disease: the Australian experience. J Pediatr Gastroenterol Nutr. 2015 Jun; 60(6):717-22. Abstract OBJECTIVES: Parenting stress, problems in family functioning, and lack of fathers' engagement in treatment are associated with poor quality of life in children with chronic illnesses. The aim of the present study was to examine these characteristics in families of infants with serious liver disease in Australia, to inform the provision of mental health care for these families. METHODS: Published on: Jun-2015 Read more

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