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Usefulness of indirect noninvasive methods in predicting progression to cirrhosis in chronic hepatitis C http://www.ncbi.nlm.nih.gov/pubmed/26043289 Vergara M, Bejarano G, Dalmau B, Gil M, Miquel M, Sanchez-Delgado J, Casas M, Puig J, Martinez-Bauer E, Dosal A, Lopez M, Moreno L, Valero O, Bella MR, Calvet X. Usefulness of indirect noninvasive methods in predicting progression to cirrhosis in chronic hepatitis C. Eur J Gastroenterol Hepatol. 2015 Jul;27(7):826-33. Abstract BACKGROUND AND AIMS: The ability of noninvasive methods to predict the development of cirrhosis has not been established. We evaluated the ability of three noninvasive methods [the Forns index, the aspartate aminotransferase-to-platelet ratio index (APRI), and the Non-Invasive Hepatitis-C-related Cirrhosis Early Detection (NIHCED) score] to determine the risk of developing cirrhosis in chronic hepatitis C. Published on: Jul-2015 Read more	Increase of Serum γ-Glutamyltransferase Associated With Development of Cirrhotic Cystic Fibrosis Liver Disease http://www.ncbi.nlm.nih.gov/pubmed/25658056 Bodewes FA, van der Doef HP, Houwen RH, Verkade HJ. Increase of Serum γ-Glutamyltransferase Associated With Development of Cirrhotic Cystic Fibrosis Liver Disease. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):113-8. Abstract BACKGROUND: Identification of patients at risk for developing cirrhotic cystic fibrosis liver disease (CCFLD) is essential for targeting potentially preventive treatment. We studied the evolution of serum liver enzymes and thrombocyte counts as predictors of CCFLD development. METHODS: Published on: Jul-2015 Read more
EASL Recommendations on Treatment of Hepatitis C 2015 http://www.ncbi.nlm.nih.gov/pubmed/25911336 European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu. EASL Recommendations on Treatment of Hepatitis C 2015. J Hepatol. 2015 Jul; 63(1):199-236. Published on: Jul-2015	Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure http://www.ncbi.nlm.nih.gov/pubmed/25859823 Alonso EM, James LP, Zhang S, Squires RH; Pediatric Acute Liver Failure Study Group. Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):102-7. Abstract OBJECTIVES: Previous studies in patients with acute liver failure identified acetaminophen (APAP) protein adducts in the serum of 12% and 19% of children and adults, respectively, with acute liver failure of indeterminate etiology. This article details the testing of APAP adducts in a subset (n = 393) of patients with varied diagnoses in the Pediatric Acute Liver Failure Study Group (PALFSG). METHODS: Published on: Jul-2015 Read more
Hepatic steatosis in Wilson disease - Role of copper and PNPLA3 mutations http://www.ncbi.nlm.nih.gov/pubmed/25678388 Stättermayer AF, Traussnigg S, Dienes HP, Aigner E, Stauber R, Lackner K, Hofer H, Stift J, Wrba F, Stadlmayr A, Datz C, Strasser M, Maieron A, Trauner M, Ferenci P. Hepatic steatosis in Wilson disease - Role of copper and PNPLA3 mutations. J Hepatol. 2015 Jul; 63(1):156-63. Abstract BACKGROUND & AIMS: Published on: Jul-2015 Read more	Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension http://www.ncbi.nlm.nih.gov/pubmed/25651489 Childhood Liver Disease Research Network (ChiLDReN). Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension. Extra hepatic portal hypertension Teckman JH, Rosenthal P, Abel R, Bass LM, Michail S, Murray KF, Rudnick DA, Thomas DW, Spino C, Arnon R, Hertel PM, Heubi J, Kamath BM, Karnsakul W, Loomes KM, Magee JC, Molleston JP, Romero R, Shneider BL, Sherker AH, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN). Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):94-101. Abstract OBJECTIVES: Published on: Jul-2015 Read more
Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice http://www.ncbi.nlm.nih.gov/pubmed/25681557 drug induced liver injury Kim YH, Hwang JH, Kim KS, Noh JR, Choi DH, Kim DK, Tadi S, Yim YH, Choi HS, Lee CH. Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice. J Hepatol. 2015 Jul; 63(1):75-82. Abstract BACKGROUND & AIMS: Published on: Jul-2015 Read more	Bile Ducts in Regenerative Liver Nodules of Alagille Patients Are Not the Result of Genetic Mosaicism http://www.ncbi.nlm.nih.gov/pubmed/25643021 – allagile syndrome Rougemont AL, Alvarez F, McLin VA, Guiochon-Mantel A, Bouligand J, Clément S, Tonson La Tour A, Wildhaber BE, Rubbia-Brandt L, Sartelet H. Bile Ducts in Regenerative Liver Nodules of Alagille Patients Are Not the Result of Genetic Mosaicism. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):91-3. Published on: Jul-2015 Read more
Non-selective β-blockers are associated with improved survival in patients with ascites listed for liver transplantation http://www.ncbi.nlm.nih.gov/pubmed/25281417 Leithead JA, Rajoriya N, Tehami N, Hodson J, Gunson BK, Tripathi D, Ferguson JW. Non-selective β-blockers are associated with improved survival in patients with ascites listed for liver transplantation. Gut. 2015 Jul;64(7):1111-9. Abstract OBJECTIVE: Recent data have suggested that non-selective β-blockers (NSBB) are associated with increased mortality in patients with cirrhosis and refractory ascites. However, other evidence implies that NSBB may be beneficial in this setting by reducing bacterial translocation. Our aim was to determine whether NSBB use was a risk factor for mortality in patients with end-stage chronic liver disease and ascites awaiting liver transplantation. DESIGN: Published on: Jul-2015 Read more	Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/pubmed/25729888 Jahnel J, Zöhrer E, Alisi A, Ferrari F, Ceccarelli S, De Vito R, Scharnagl H, Stojakovic T, Fauler G, Trauner M, Nobili V. Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):85-90. Abstract OBJECTIVE: Because the prevalence of obesity in children is increasing, the frequency of pediatric nonalcoholic fatty liver disease(NAFLD) is growing. A reliable noninvasive biomarker for monitoring progression of liver fibrosis would be useful. In cirrhotic personsserum bile acid (BA) levels are significantly elevated. We hypothesized that BA levels and composition in pediatric NAFLD vary depending on the stage of fibrosis. METHODS: Published on: Jul-2015 Read more

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