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Our vitamin D needs are met from the nutrients we consume and a hormone produced in the body. A new study says that a low status of vitamin D triggers non-alcoholic fatty liver disease in children.

 

Researchers at the King's College Hospital Paediatric Liver Centre in collaboration with University of Surrey's School of Biosciences and Medicine investigated the link between low level of Vitamin D and non alcoholic fatty liver disease (NAFLD) in the U.K. children and found a genetic variant associated with the severity of the disease.

For this study, the researchers analysed the medical records of over 120 paediatric patients with NAFLD. 

 

http://www.ncbi.nlm.nih.gov/pubmed/24492755

Theocharidou E, Pieri G, Mohammad AO, Cheung M, Cholongitas E, Banwari A, Burroughs AK. The Royal Free Hospital Score: A Calibrated Prognostic Model for Patients With Cirrhosis Admitted to Intensive Care Unit. Comparison with Current Models and CLIF-SOFA Score. Am J Gastroenterol. 2014 Apr; 109(4): 554-62.

Abstract

OBJECTIVES:

Published on: 
Apr-2014

Dr Seema Alam
Additional Professor (Pediatric Hepatology)
Institute of Liver and Biliary Sciences,
D-1, Vasant Kunj,
New Delhi 110070
Phone: 011 46300000
Email: seema_alam@hotmail.com

Dr Vidyut Bhatia,
drvidyut@gmail.com;
Apollo Hospitals,
Noida Sector 26,
Noida 201301
Email: drvidyut@gmail.com

Dr. V S Sankarnarayan,
MD Paediatric Gastroenterology
Madras Medical College & Institute of Child Health Hospital,
E.V.R Periyar Salai,
Park Town,
Chennai 600 003
Email: drvssankaranarayanan@gmail.com

Dr Aabha Nagral, MD, DNB
Coordinator, Department of Gastroenterology
Jaslok Hospital and Research Center
15 - Dr. Deshmukh Marg, Peddar Road,
Mumbai 400 026.
Phone: 022 66573333 / 66573010
Phone: 022 24222160 Clinic
Email: pedliver@gmail.com

http://www.ncbi.nlm.nih.gov/pubmed/24423432

Deneau M, Book LS, Guthery SL, Jensen MK. Outcome after discontinuation of Immune-suppression in children with autoimmune hepatitis: a population-based study. J Pediatr. 2014 Apr; 164(4): 714-719.

Abstract

OBJECTIVE:

To assess sustained immunosuppression-free remission (SIFR) in children with autoimmune hepatitis (AIH).

STUDY DESIGN:

We retrospectively reviewed all children with AIH in the region between 1986 and 2011 using a population-based methodology.

RESULTS:

Published on: 
Apr-2014

Centre for Human Genetics

Dr Meenakshi Bhat,
Consultant in Clinical Genetics,
Biotech Park, Next To Arvind Mills,
1st Phase, Electronic City,
Bangalore - 560100
Email: bhat.meena@gmail.com

Institute of Human Genetics

FrigeHouse,
Jodhpur Village Road,
Satellite,
Ahmedabad 380 015.
Phone: +91 079 26921414  
Email: jshethad1@gmail.com
www.geneticcentre.org

NIRMAN

Dr. Anil B. Jalan
Navi Mumbai Institute of Research in Mental and Neurological Handicap
A – 103, Vardhaman Chambers,
Sector 17, Vashi,
Navi Mumbai 400 705
Email: jalananil@yahoo.com
www.metabolicerror.com

http://www.ncbi.nlm.nih.gov/pubmed/24360992

Molleston JP, Schwimmer JB, Yates KP, Murray KF, Cummings OW, Lavine JE, Brunt
EM, Scheimann AO, Unalp-Arida A; NASH Clinical Research Network. Histological abnormalities in children with nonalcoholic fatty liver disease and normal or mildly elevated alanine aminotransferase levels. J Pediatr. 2014 Apr; 164(4): 707-713.

Abstract

OBJECTIVE:

To investigate the histological spectrum of nonalcoholic fatty liver disease (NAFLD) in children with normal, mildly elevated (26-50 U/L boys, 23-44 U/L girls), or elevated (>50 U/L in boys, >44 U/L in girls) serum alanine aminotransferase (ALT) levels.

STUDY DESIGN:

Published on: 
Apr-2014

http://www.ncbi.nlm.nih.gov/pubmed/24224950

Miyaoka Y, Amano Y, Ueno S, Izumi D, Mikami H, Yazaki T, Okimoto E, Sonoyama T, Ito S, Fujishiro H, Kohge N, Imaoka T. The role of enhanced multi-detector-row computed tomography before urgent endoscopy in acute upper gastrointestinal bleeding. J Gastroenterol Hepatol. 2014 Apr; 29(4): 716-22.

Abstract

BACKGROUND AND AIM:

Multi-detector-row computed tomography (MDCT) has been reported to be a potentially useful modality for detection of the bleeding origin in patients with acute upper massive gastrointestinal (GI) bleeding. The purpose of this study is to investigate the efficacy of MDCT as a routine method for detecting the origin of acute upper GI bleeding prior to urgent endoscopy.

METHODS:

Published on: 
Apr-2014

http://www.ncbi.nlm.nih.gov/pubmed/24321532

Sundaram SS, Sokol RJ, Capocelli KE, Pan Z, Sullivan JS, Robbins K, Halbower AC. Obstructive sleep apnea and hypoxemia are associated with advanced liver histology in pediatric nonalcoholic fatty liver disease. J Pediatr. 2014 Apr; 164(4): 699-706.

Abstract

OBJECTIVE:

To determine whether obstructive sleep apnea (OSA) and/or nocturnal hypoxemia are associated with the severity of liver injury in patients with pediatric nonalcoholic fatty liver disease (NAFLD).

STUDY DESIGN:

Published on: 
Apr-2014

http://www.ncbi.nlm.nih.gov/pubmed/24117967

Qi X, Liu L, Bai M, Chen H, Wang J, Yang Z, Han G, Fan D. Transjugular intrahepatic porto-systemic shunt in combination with or without variceal embolization for the prevention of variceal rebleeding: a meta-analysis. J Gastroenterol Hepatol. 2014 Apr; 29(4): 688-96.

Abstract

BACKGROUND AND AIM:

Published on: 
Apr-2014

http://www.ncbi.nlm.nih.gov/pubmed/24231645

Wang P, Su H, Underhill J, Blackmore LJ, Longhi MS, Grammatikopoulos T, Okokon EV, Davies ET, Vergani D, Mieli-Vergani G, Ma Y. Autoantibody and human leukocyte antigen profiles in children with autoimmune liver disease and their first-degree relatives. J Pediatr Gastroenterol Nutr. 2014 Apr; 58(4):457-62.

Abstract

OBJECTIVE:

Familial clustering of juvenile autoimmune liver disease (AILD), including autoimmune hepatitis and autoimmune sclerosing cholangitis (ASC), is rare, despite a high prevalence of autoimmune disorders in AILD families.

METHODS:

Published on: 
Apr-2014

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