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Chinese Children With Chronic Intrahepatic Cholestasis and High γ-Glutamyl Transpeptidase: Clinical Features and Association With ABCB4 Mutations

J Pediatr Gastroenterol Nutr. 2012 Aug;55(2):150-6.

Chinese Children With Chronic Intrahepatic Cholestasis and High γ-Glutamyl Transpeptidase: Clinical Features and Association With ABCB4 Mutations.
Fang LJ, Wang XH, Knisely AS, Yu H, Lu Y, Liu LY, Wang JS.
*Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China †Institute of Liver Studies, King's College Hospital Denmark Hill, London, UK.

Abstract

OBJECTIVE:  The aims of the present study was to study the significance of ABCB4 mutations in mainland Chinese children with chronic intrahepatic cholestasis and to correlate genetic findings with clinical features and response to ursodeoxycholic acid (UDCA) therapy.

Published on: 
Aug-2012
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Predictors of clinically significant upper gastrointestinal hemorrhage among children with hematemesis

J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):737-43.

Predictors of clinically significant upper gastrointestinal hemorrhage among children with hematemesis.
Freedman SB, Stewart C, Rumantir M, Thull-Freedman JD.
Division of Paediatric Emergency Medicine, The Hospital for Sick Children, Toronto, ON, Canada. stephen.freedman@sickkids.ca

Abstract

OBJECTIVES: The aim of the study was to determine the proportion of children with hematemesis who experience a clinically significant upper gastrointestinal hemorrhage (UGIH) and to identify variables predicting their occurrence.

Published on: 
Jun-2012
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Endoscopic retrograde cholangiopancreatography in neonatal cholestasis

J Pediatr Gastroenterol Nutr. 2012 Aug;55(2):142-5.

Endoscopic retrograde cholangiopancreatography in neonatal cholestasis.
Shteyer E, Wengrower D, Benuri-Silbiger I, Gozal D, Wilschanski M, Goldin E.
*Pediatric Gastroenterology Unit †Department of Gastroenterology ‡Division of Anesthesiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Abstract

BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is not as widely used in children as in adults and is performed in few specialized centers. The aim of the present study was to review the experience of ERCP in children younger than 3 months in a national referral center.

Published on: 
Aug-2012
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Feasibility and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) in children

J Pediatr Gastroenterol Nutr. 2012 May;54(5):594-600.

Feasibility and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) in children.
Di Giorgio A, Agazzi R, Alberti D, Colledan M, D'Antiga L.
Paediatric Hepatology, Gastroenterology and Transplantation, Ospedali Riuniti di Bergamo, Bergamo, Italy.

Abstract

OBJECTIVES: Transjugular intrahepatic portosystemic shunt (TIPS) is a valuable tool in managing complications of severe portal hypertension (PH) in adults. In children, TIPS is regarded as a temporary and technically demanding procedure. We report the first paediatric series of TIPS and review its feasibility and efficacy in children.

Published on: 
May-2012
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Evaluation of risk factors for bleeding after liver biopsy in children

J Pediatr Gastroenterol Nutr. 2012 Jul;55(1):82-7.

Evaluation of risk factors for bleeding after liver biopsy in children.
Westheim BH, Østensen AB, Aagenæs I, Sanengen T, Almaas R.
Department of Pediatric Research, Rikshospitalet, Oslo University Hospital, Oslo, Norway.

Abstract

OBJECTIVES: Acetylsalicylic acid is used in liver-transplanted children to prevent thrombosis of the hepatic artery. We evaluated whether acetylsalicylic acid and other risk factors were associated with bleeding after percutaneous liver biopsy.

Published on: 
Jul-2012
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Polymorphism in pediatric nonalcoholic fatty liver disease

J Pediatr Gastroenterol Nutr. 2012 May;54(5):588-93.

LPIN1 rs13412852 polymorphism in pediatric nonalcoholic fatty liver disease.
Valenti L, Motta BM, Alisi A, Sartorelli R, Buonaiuto G, Dongiovanni P, Rametta R, Pelusi S, Fargion S, Nobili V.
Department of Internal Medicine, Università degli Studi, Ospedale Maggiore Policlinico Ca' Granda IRCCS, Milan, Italy. luca.valenti@unimi.it

Abstract

OBJECTIVES: The aim of the present study was to evaluate whether the lipin1 rs13412852 C>T polymorphism is associated with nonalcoholic steatohepatitis and fibrosis in pediatric Italian patients with nonalcoholic fatty liver disease (NAFLD).

Published on: 
May-2012
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Congenital hepatic fibrosis and autosomal recessive polycystic kidney disease

J Pediatr Gastroenterol Nutr. 2012 May;54(5):580-7.

Congenital hepatic fibrosis and autosomal recessive polycystic kidney disease.
Srinath A, Shneider BL.
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.

Abstract

OBJECTIVES: The published natural history of congenital hepatic fibrosis (CHF) was examined to inform clinical decision making in autosomal recessive polycystic kidney disease (ARPKD).

Published on: 
May-2012
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Parenteral plant sterols and intestinal failure-associated liver disease in neonates

J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):803-11.

Parenteral plant sterols and intestinal failure-associated liver disease in neonates.
Kurvinen A, Nissinen MJ, Andersson S, Korhonen P, Ruuska T, Taimisto M, Kalliomäki M, Lehtonen L, Sankilampi U, Arikoski P, Saarela T, Miettinen TA, Gylling H, Pakarinen MP.
Section of Pediatric Surgery, Children's Hospital, University of Helsinki, Helsinki, Finland. annika.kurvinen@helsinki.fi

Abstract

OBJECTIVES: We prospectively evaluated incidence of prolonged (>28 days) parenteral nutrition (PN), associated complications, and significance of parenteral plant sterols (PS) in neonatal intestinal failure-associated liver disease (IFALD) compared with children.

Published on: 
Jun-2012
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Intracranial hemorrhage associated with vitamin K-deficiency bleeding in patients with biliary atresia: focus on long-term outcomes

J Pediatr Gastroenterol Nutr. 2012 Apr;54(4):552-7.

Intracranial hemorrhage associated with vitamin K-deficiency bleeding in patients with biliary atresia: focus on long-term outcomes.
Alatas FS, Hayashida M, Matsuura T, Saeki I, Yanagi Y, Taguchi T.
Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Abstract

Published on: 
Apr-2012
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