Alagille syndrome

Clinical, pathological and genetic characteristics of 17 unrelated children with Alagille Syndrome

Event-free survival of maralixibat-treated patients with Alagille syndrome compared to a real-world cohort from GALA

Clinical and genetic analysis in Chinese children with Alagille syndrome

Clinical and genetic analysis in Chinese children with Alagille syndrome

Maralixibat Treatment Response in Alagille Syndrome Is Associated with Improved Health-Related Quality of Life

Natural History of Liver Disease in a Large International Cohort of Children with Alagille syndrome: Results from The GALA Study

A Case of Infantile Alagille Syndrome With Severe Dyslipidemia: New Insight into Lipid Metabolism and Therapeutics

Intrahepatic cholangiocyte regeneration from an Fgf-dependent extrahepatic progenitor niche in a zebrafish model of Alagille Syndrome

Outcomes in Patients with Alagille Syndrome and Complex Pulmonary Artery Disease

Novel JAG1 Deletion Variant in Patient with Atypical Alagille Syndrome.

Living donor liver transplantation in Alagille syndrome-Single center experience from south Asia.

Clinical Features and Genetic Analysis of Pediatric Patients with Alagille Syndrome Presenting Initially with Liver Function Abnormalities

Systematic Review: the Epidemiology, Natural History and Burden of Alagille Syndrome

Solitary Hepatic Nodule Adjacent to the Right Portal Vein: A Common Finding of Alagille Syndrome?

Bile Ducts in Regenerative Liver Nodules of Alagille Patients Are Not the Result of Genetic Mosaicism

Management of Cholestatic Pruritus in Paediatric Patients With Alagille Syndrome: The King's College Hospital Experience.

Alagille syndrome

What is Alagille syndrome?

It is a Genetic disorder(JAG 1 gene)  also known as arteriohepatic dysplasia.Children  usually have a liver disease characterized by a progressive loss of the bile ducts within the liver over the first year of life and narrowing of the bile ducts outside the liver. This leads to a buildup of bile in the liver, causing damage to liver cells. Scarring may occur and lead to cirrhosis in about 30 to 50 percent of affected children.

How common is this condition?

The incidence rate is approximately 1 case in every 100,000 live births.

What is the cause and risk of developing syndrome?

Read more

CLF Intro movie

Financial Aid Offered by Trusts

Follow us on: