Event Videos

Spleen Stiffness in Patients With Cirrhosis in Predicting Esophageal Varices

Am J Gastroenterol. 2013 Jul;108(7):1101-7.
Sharma P, Kirnake V, Tyagi P, Bansal N, Singla V, Kumar A, Arora A.
http://www.ncbi.nlm.nih.gov/pubmed/23629600

OBJECTIVES: Screening for esophageal varices (EV) is recommended in patients with cirrhosis. Noninvasive tests had shown varying sensitivity (Se) and specifi city (Sp) for predicting EV. Splenomegaly is a common fi nding in liver cirrhosis because of portal and splenic congestion. These changes can be quantifi ed by transient elastography; hence, the aim of this study was to investigate the utility of spleen
stiffness (SS) in evaluating EV in comparison with other noninvasive tests.

Published on: 
Jul-2013
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Unconjugated bilirubin, a potent endogenous antioxidant, is decreased in patients with non-alcoholic steatohepatitis and advanced fibrosis.

J Gastroenterol Hepatol. 2013 Jul;28(7):1202-8.
Salomone F, Li Volti G, Rosso C, Grosso G, Bugianesi E.
http://www.ncbi.nlm.nih.gov/pubmed/23425054

Abstract
Background and Aim: Oxidative stress is considered a key element in the progression of
non-alcoholic fatty liver to non-alcoholic steatohepatitis (NASH). Unconjugated bilirubin
is the main endogenous lipid antioxidant and is cytoprotective in different tissues and
organs. In this study, it was evaluated if unconjugated bilirubin levels are associated with
the degree of liver injury in patients with non-alcoholic fatty liver disease.
Methods: Two hundred and eighty-five patients were retrospectively evaluated with

Published on: 
Jul-2013
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Drug-induced Liver Injury Caused by Intravenously Administered Medications: The Drug-induced Liver Injury Network Experience

J Clin Gastroenterol. 2013 Jul;47(6):553-8.
Ghabril M, Fontana R, Rockey D, Jiezhun G, Chalasani N.
http://www.ncbi.nlm.nih.gov/pubmed/23388845

Background and Aims: Idiosyncratic drug-induced liver injury (DILI) can be caused by intravenous (IV) medications, but the characteristics of DILI caused by these agents are not known. The aim of this study is to characterize the clinical features of subjects with suspected DILI associated with IV agents enrolled into the Drug Induced Liver Injury Network Prospective Study.

Methods: Subjects with suspected DILI due to IV medications with probable, highly likely, or definite casuality scores were eligible.

Published on: 
Jul-2013
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Dietary Fructose Intake and Severity of Liver Disease in Hepatitis C Virus-infected Patients

J Clin Gastroenterol 2013 Jul ;47:545–552

Tyson GL, Richardson PA, White DL, Kuzniarek J, Ramsey DJ, Tavakoli-Tabasi S, El-Serag HB.

http://www.ncbi.nlm.nih.gov/pubmed/23426443

Background and Goals: Dietary fructose intake in the United States has been increasing, and fructose intake has been associated with the metabolic syndrome and hepatic steatosis. This study aimed to determine whether dietary fructose intake is associated with advanced hepatic fibrosis and inflammation in an hepatitis C virus (HCV)-infected male population.

Published on: 
Jul-2013
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Cholestasis in a Patient With Gallstones and a Normal Gamma-Glutamyl Transferase

Hepatology. 2013 Jun;57(6):2539-41.
Moghadamrad S, Montani M, Weimann R, De Gottardi A.
http://www.ncbi.nlm.nih.gov/pubmed/23446990

Cholestasis with normal gamma glutamyl transferase characterizes functional deficiencies
in the gene ABCB11, which encodes the bile salt export pump (BSEP), a liver-specific
adenosine triphosphate (ATP)-binding cassette transporter. Here we report the case of a
patient presenting with features of benign recurrent intrahepatic cholestasis associated
with a heterozygous mutation in the ABCB11 gene. Immunohistochemistry showed a
gradual decrease of BSEP from zone 1 to zone 3 of the liver lobule, suggesting that the

Published on: 
Jun-2013
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